2x4a

From Proteopedia

(Difference between revisions)

Revision as of 15:04, 8 July 2020

Crystal structure of the C-terminal domain of InvA

Structural highlights

2x4a is a 1 chain structure with sequence from Salty. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	2x49
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[INVA_SALTY] Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

InvA is a prominent inner-membrane component of the Salmonella type III secretion system (T3SS) apparatus, which is responsible for regulating virulence protein export in pathogenic bacteria. InvA is made up of an N-terminal integral membrane domain and a C-terminal cytoplasmic domain that is proposed to form part of a docking platform for the soluble export apparatus proteins notably the T3SS ATPase InvC. Here, we report the novel crystal structure of the C-terminal domain of Salmonella InvA which shows a compact structure composed of four subdomains. The overall structure is unique although the first and second subdomains exhibit structural similarity to the peripheral stalk of the A/V-type ATPase and a ring building motif found in other T3SS proteins respectively.

Crystal structure of the C-terminal domain of the Salmonella type III secretion system export apparatus protein InvA.,Worrall LJ, Vuckovic M, Strynadka NC Protein Sci. 2010 Mar 19. PMID:20306492^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Worrall LJ, Vuckovic M, Strynadka NC. Crystal structure of the C-terminal domain of the Salmonella type III secretion system export apparatus protein InvA. Protein Sci. 2010 Mar 19. PMID:20306492 doi:10.1002/pro.382

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2x4a"

@@ Line 1: / Line 1: @@
 ==Crystal structure of the C-terminal domain of InvA==
-<StructureSection load='2x4a' size='340' side='right' caption='[[2x4a]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
+<StructureSection load='2x4a' size='340' side='right'caption='[[2x4a]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2x4a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4A FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2x4a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4A OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X4A FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2x49|2x49]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4a OCA], [http://pdbe.org/2x4a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4a RCSB], [http://www.ebi.ac.uk/pdbsum/2x4a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4a ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4a OCA], [http://pdbe.org/2x4a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4a RCSB], [http://www.ebi.ac.uk/pdbsum/2x4a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4a ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 33: / Line 33: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Salty]]
 [[Category: Strynadka, N C.J]]

2x4a

From Proteopedia

Revision as of 15:04, 8 July 2020

Crystal structure of the C-terminal domain of InvA

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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