5khm

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==The first BET bromodomain of BRD4 bound to compound 13 in a bivalent manner==
==The first BET bromodomain of BRD4 bound to compound 13 in a bivalent manner==
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<StructureSection load='5khm' size='340' side='right' caption='[[5khm]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
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<StructureSection load='5khm' size='340' side='right'caption='[[5khm]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5khm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KHM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5khm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KHM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5KHM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=XNH:(3~{R})-4-[2-[4-[1-(3-METHOXY-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PIPERIDIN-4-YL]PHENOXY]ETHYL]-1,3-DIMETHYL-PIPERAZIN-2-ONE'>XNH</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=XNH:(3~{R})-4-[2-[4-[1-(3-METHOXY-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PIPERIDIN-4-YL]PHENOXY]ETHYL]-1,3-DIMETHYL-PIPERAZIN-2-ONE'>XNH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5khm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5khm OCA], [http://pdbe.org/5khm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5khm RCSB], [http://www.ebi.ac.uk/pdbsum/5khm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5khm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5khm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5khm OCA], [http://pdbe.org/5khm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5khm RCSB], [http://www.ebi.ac.uk/pdbsum/5khm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5khm ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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==See Also==
==See Also==
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*[[Bromodomain-containing protein|Bromodomain-containing protein]]
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Patel, J]]
[[Category: Patel, J]]
[[Category: Bromodomain]]
[[Category: Bromodomain]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]

Revision as of 15:25, 8 July 2020

The first BET bromodomain of BRD4 bound to compound 13 in a bivalent manner

PDB ID 5khm

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