User:Eric Martz/MHC Quiz

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{<hr>'''An IgG1 molecule has a molecular weight of 150 kilo Daltons.'''}
 
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What is the approximate molecular weight of one immunoglobulin domain in kD?
 
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{ 10-13 _7 } kD.
 
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||Twelve Ig domains in one IgG1 molecule. 150/12 = 12.5 kD.
 
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'''Questions below may have <font color="red">more than one</font> correct answer.'''}
 
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{Antibody
 
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+ Binds to antigen.
 
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+ When bound to a microbe, recruits macrophages and other leukocytes to kill the microbes.
 
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+ Defends us against infections.
 
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- Carries oxygen to tissues.
 
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- Is a hormone.
 
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- Strengthens bones.
 
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Revision as of 18:24, 14 July 2020

Antibody Quiz

You will get immediate feedback when you click Submit (at the bottom of the quiz). This quiz is offered to accompany the MHC structure tutorial at MolviZ.Org.


In some cases, more than one answer may be correct.

1. What does "MHC" stand for?

Multiple Histocompatibility Complex.
Manifest Hybridoma Catalyst.
Major Histological Crevice.
Major Histocompatibility Complex.
Minor Histocompatibility Complex.

2. What does MHC class I do?

Presents peptides to CD4 "helper" T lymphocytes.
Presents peptides to CD8 "cytotoxic" T lymphocytes.
Brings peptides from the proteasome to the cell surface.
Brings peptides from the lysosome to the cell surface.
Presents shorter peptides than class II MHC.
Presents longer peptides than class II MHC.
Removes worn out proteins.
It makes antibody.
It remains bound to the cell membrane.
It is released from cells to float freely and bind to CD8.

3. Which kinds of cells express MHC class I?

B lymphocytes.
T lymphocytes.
Red blood cells.
Liver cells.
Macrophages.
Dendritic cells.

4. Why do some viruses impair the expression of MHC class I on their host cells?

To hide from Natural Killer Cells.
To hide from CD8 cytotoxic T cells.
To attract CD4 helper T cells.
To conserve virus peptides.

5. What happens to cells that express little or no MHC class I?

They are attacked by Natural Killer Cells.
They are attacked by Cytotoxic T Lymphocytes.
Nothing.
They are recycled by the lymphatic system.
They lose their ability to activate CD8 T lymphocytes.

6. Beta-2 microglobulin

Binds to CD8.
Has a peptide-binding cleft.
Is part of the MHC class I protein.
Is part of the MHC class II protein.
Activates T cytotoxic cells.
Is an anchor residue.

7. The peptide-binding cleft

Has closed ends in MHC class I.
Has closed ends in MHC class II.
Has open ends in MHC class I.
Has open ends in MHC class II.
In MHC class I, binds only peptides with specific anchor residues.

8. T lymphocytes examine

Peptide side chains that are buried in the cleft.
Peptide side chains that are exposed.
Both MHC classes.

9. How many polypeptide chains make up the MHC I peptide-binding cleft, not counting the antigenic peptide?

→

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Eric Martz

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