1c4z

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[[Image:1c4z.gif|left|200px]]
[[Image:1c4z.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1c4z |SIZE=350|CAPTION= <scene name='initialview01'>1c4z</scene>, resolution 2.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1c4z", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span>
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{{STRUCTURE_1c4z| PDB=1c4z | SCENE= }}
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|RELATEDENTRY=[[1ubq|1UBQ]], [[1d5f|1D5F]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4z OCA], [http://www.ebi.ac.uk/pdbsum/1c4z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1c4z RCSB]</span>
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'''STRUCTURE OF E6AP: INSIGHTS INTO UBIQUITINATION PATHWAY'''
'''STRUCTURE OF E6AP: INSIGHTS INTO UBIQUITINATION PATHWAY'''
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[[Category: Pavletich, N P.]]
[[Category: Pavletich, N P.]]
[[Category: Wang, G.]]
[[Category: Wang, G.]]
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[[Category: bilobal structure]]
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[[Category: Bilobal structure]]
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[[Category: e2 ubiquitin conjugating enzyme]]
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[[Category: E2 ubiquitin conjugating enzyme]]
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[[Category: e3 ubiquitin ligase]]
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[[Category: E3 ubiquitin ligase]]
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[[Category: elongated shape]]
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[[Category: Elongated shape]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:20:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:14:36 2008''
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Revision as of 09:20, 2 May 2008

Image:1c4z.gif

Template:STRUCTURE 1c4z

STRUCTURE OF E6AP: INSIGHTS INTO UBIQUITINATION PATHWAY


Overview

The E6AP ubiquitin-protein ligase (E3) mediates the human papillomavirus-induced degradation of the p53 tumor suppressor in cervical cancer and is mutated in Angelman syndrome, a neurological disorder. The crystal structure of the catalytic hect domain of E6AP reveals a bilobal structure with a broad catalytic cleft at the junction of the two lobes. The cleft consists of conserved residues whose mutation interferes with ubiquitin-thioester bond formation and is the site of Angelman syndrome mutations. The crystal structure of the E6AP hect domain bound to the UbcH7 ubiquitin-conjugating enzyme (E2) reveals the determinants of E2-E3 specificity and provides insights into the transfer of ubiquitin from the E2 to the E3.

About this Structure

1C4Z is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade., Huang L, Kinnucan E, Wang G, Beaudenon S, Howley PM, Huibregtse JM, Pavletich NP, Science. 1999 Nov 12;286(5443):1321-6. PMID:10558980 Page seeded by OCA on Fri May 2 12:20:00 2008

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