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Major histocompatibility complex
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== Function == | == Function == | ||
| - | ''' Major Histocompatibility Complex''' (MHC) | + | ''' Major Histocompatibility Complex''' (MHC) molecules bind peptides derived from degraded proteins and present these peptides on the surface of the cell. T-cells or natural killer receptors recognize the MHC:peptide complex and trigger an immune response if the presented peptide (“antigen”) is suggestive of a pathogenic or foreign protein. Thus, MHC molecules allow for immune system detection of intracellular activity, making them an essential part of the organism’s immune system. |
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* '''MHC class I''' ([[Major Histocompatibility Complex Class I]]) are found in all nucleated cells. These cell surface proteins display peptides from cellular intrinsic proteins<ref>PMID:18675588</ref>. For more details see <br /> | * '''MHC class I''' ([[Major Histocompatibility Complex Class I]]) are found in all nucleated cells. These cell surface proteins display peptides from cellular intrinsic proteins<ref>PMID:18675588</ref>. For more details see <br /> | ||
*[[Effect of HCMV on Major Histocompatibility Complex Class I]]<br /> | *[[Effect of HCMV on Major Histocompatibility Complex Class I]]<br /> | ||
Revision as of 19:30, 21 July 2020
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References
- ↑ Raghavan M, Del Cid N, Rizvi SM, Peters LR. MHC class I assembly: out and about. Trends Immunol. 2008 Sep;29(9):436-43. doi: 10.1016/j.it.2008.06.004. PMID:18675588 doi:http://dx.doi.org/10.1016/j.it.2008.06.004
- ↑ Holling TM, Schooten E, van Den Elsen PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum Immunol. 2004 Apr;65(4):282-90. PMID:15120183 doi:http://dx.doi.org/10.1016/j.humimm.2004.01.005
- ↑ Liu J, Chen KY, Ren EC. Structural insights into the binding of hepatitis B virus core peptide to HLA-A2 alleles: Towards designing better vaccines. Eur J Immunol. 2011 Jul;41(7):2097-106. doi: 10.1002/eji.201041370. PMID:21538979 doi:10.1002/eji.201041370
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