1c7c

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[[Image:1c7c.gif|left|200px]]
[[Image:1c7c.gif|left|200px]]
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{{Structure
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|PDB= 1c7c |SIZE=350|CAPTION= <scene name='initialview01'>1c7c</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1c7c", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
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|GENE=
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{{STRUCTURE_1c7c| PDB=1c7c | SCENE= }}
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|RELATEDENTRY=[[1c7b|1C7B]], [[1c7d|1C7D]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c7c OCA], [http://www.ebi.ac.uk/pdbsum/1c7c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1c7c RCSB]</span>
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}}
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'''DEOXY RHB1.1 (RECOMBINANT HEMOGLOBIN)'''
'''DEOXY RHB1.1 (RECOMBINANT HEMOGLOBIN)'''
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Brucker, E A.]]
[[Category: Brucker, E A.]]
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[[Category: blood substitute]]
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[[Category: Blood substitute]]
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[[Category: heme]]
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[[Category: Heme]]
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[[Category: oxygen delivery vehicle]]
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[[Category: Oxygen delivery vehicle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:25:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:16:01 2008''
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Revision as of 09:25, 2 May 2008

Image:1c7c.gif

Template:STRUCTURE 1c7c

DEOXY RHB1.1 (RECOMBINANT HEMOGLOBIN)


Overview

The crystal structures of three recombinant human hemoglobins, rHb1. 0, rHb1.1 and rHb1.2, have been determined in the deoxy state at 1.8 A resolution. Two of the three proteins, rHb1.1 and rHb1.2, contain a genetic fusion of the alpha subunits, a one- or two-glycine link, respectively, whereas rHb1.0 does not. The glycine crosslinks, localized between one N- and C--termini pair of the alpha subunits in the deoxy crystalline state, do not perturb the overall tertiary or quaternary or even the local structure of hemoglobin. Therefore, genetic fusion to prevent the dissociation of the hemoglobin tetramer, thereby inhibiting renal clearance based upon molecular size, is a structurally conservative method to stabilize hemoglobin for use as an oxygen-delivery therapeutic.

About this Structure

1C7C is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Genetically crosslinked hemoglobin: a structural study., Brucker EA, Acta Crystallogr D Biol Crystallogr. 2000 Jul;56(Pt 7):812-6. PMID:10930828 Page seeded by OCA on Fri May 2 12:25:02 2008

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