6lx3

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==Cryo-EM structure of human secretory immunoglobulin A==
==Cryo-EM structure of human secretory immunoglobulin A==
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<StructureSection load='6lx3' size='340' side='right'caption='[[6lx3]]' scene=''>
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<StructureSection load='6lx3' size='340' side='right'caption='[[6lx3]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LX3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LX3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6lx3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LX3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LX3 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lx3 OCA], [http://pdbe.org/6lx3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lx3 RCSB], [http://www.ebi.ac.uk/pdbsum/6lx3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lx3 ProSAT]</span></td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IGHA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), JCHAIN, IGCJ, IGJ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PIGR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lx3 OCA], [http://pdbe.org/6lx3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lx3 RCSB], [http://www.ebi.ac.uk/pdbsum/6lx3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lx3 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
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== Function ==
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[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. [[http://www.uniprot.org/uniprot/PIGR_HUMAN PIGR_HUMAN]] This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. [[http://www.uniprot.org/uniprot/IGJ_HUMAN IGJ_HUMAN]] Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.[UniProtKB:P01592]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Secretory Immunoglobulin A (SIgA) is the most abundant antibody at the mucosal surface. It possesses two additional subunits besides IgA: the joining chain (J-chain) and secretory component (SC). SC is the ectodomain of the polymeric immunoglobulin receptor (pIgR), which functions to transport IgA to the mucosa. How the J-chain and pIgR/SC facilitate the assembly and secretion of SIgA remains incompletely understood. Furthermore, during the infection of Streptococcus pneumoniae, the pneumococcal adhesin SpsA hijacks pIgR/SC and SIgA to gain entry to human cells and evade host defense. How SpsA targets pIgR/SC and SIgA also remains elusive. Here we report a cryo-electron microscopy structure of the Fc region of IgA1 (Fcalpha) in complex with the J-chain and SC (Fcalpha-J-SC), which reveals the organization principle of SIgA. We also present a structure of Fcalpha-J-SC complexed with SpsA, which uncovers the specific interactions between SpsA and human pIgR/SC. These results advance the molecular understanding of SIgA and shed light on S. pneumoniae pathogenesis.
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Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin.,Wang Y, Wang G, Li Y, Zhu Q, Shen H, Gao N, Xiao J Cell Res. 2020 May 12. pii: 10.1038/s41422-020-0336-3. doi:, 10.1038/s41422-020-0336-3. PMID:32398862<ref>PMID:32398862</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6lx3" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Li Y]]
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[[Category: Li, Y]]
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[[Category: Wang G]]
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[[Category: Wang, G]]
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[[Category: Wang Y]]
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[[Category: Wang, Y]]
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[[Category: Xiao J]]
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[[Category: Xiao, J]]
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[[Category: Dimer]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin]]
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[[Category: Secreted]]
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[[Category: Transcytosis]]

Revision as of 11:20, 22 July 2020

Cryo-EM structure of human secretory immunoglobulin A

PDB ID 6lx3

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