6x0o
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6x0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x0o OCA], [http://pdbe.org/6x0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6x0o RCSB], [http://www.ebi.ac.uk/pdbsum/6x0o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6x0o ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6x0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x0o OCA], [http://pdbe.org/6x0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6x0o RCSB], [http://www.ebi.ac.uk/pdbsum/6x0o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6x0o ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Arabinosyltransferase B (EmbB) belongs to a family of membrane-bound glycosyltransferases that build the lipidated polysaccharides of the mycobacterial cell envelope, and are targets of anti-tuberculosis drug ethambutol. We present the 3.3 A resolution single-particle cryo-electron microscopy structure of Mycobacterium smegmatis EmbB, providing insights on substrate binding and reaction mechanism. Mutations that confer ethambutol resistance map mostly around the putative active site, suggesting this to be the location of drug binding. | ||
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| + | Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis.,Tan YZ, Rodrigues J, Keener JE, Zheng RB, Brunton R, Kloss B, Giacometti SI, Rosario AL, Zhang L, Niederweis M, Clarke OB, Lowary TL, Marty MT, Archer M, Potter CS, Carragher B, Mancia F Nat Commun. 2020 Jul 7;11(1):3396. doi: 10.1038/s41467-020-17202-8. PMID:32636380<ref>PMID:32636380</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6x0o" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 11:45, 22 July 2020
Single-Particle Cryo-EM Structure of Arabinosyltransferase EmbB from Mycobacterium smegmatis
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Categories: Indolylacetylinositol arabinosyltransferase | Large Structures | Mycs2 | Archer, M | Brunton, R | Carragher, B | Clarke, O B | Giacometti, S I | Keener, J E | Kloss, B | Lowary, T L | Mancia, F | Marty, M T | Niederweis, M | Potter, C S | Rodrigues, J | Rosario, A L | Tan, Y Z | Zhang, L | Zheng, R B | Glycosyltransferase | Membrane protein | Nanodisc
