2xna

From Proteopedia

(Difference between revisions)

Revision as of 12:13, 22 July 2020

Crystal structure of the complex between human T cell receptor and staphylococcal enterotoxin

Structural highlights

2xna is a 3 chain structure with sequence from "micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885 and Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	1enf, 2esv, 1f77, 1qrn, 1kgc, 2bnr, 2ak4, 2gj6, 2cdg, 2bnu, 2eys, 1mi5, 2cdf, 1fyt, 1ymm, 1ewc, 1j8h, 1zgl, 2axh, 1ktk, 2eyt, 2bnq, 1oga, 2eyr, 2cde, 2xn9
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ETXH_STAAU] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

Publication Abstract from PubMed

Superantigens (SAgs) are bacterial toxins that interact with immunoreceptors, T cell receptor (TCR) and major histocompatibility complex (MHC) class II, conventionally through the variable beta-domain of TCR (TCRVbeta). They induce a massive release of cytokines, which can lead to diseases such as food poisoning and toxic shock syndrome. In this study, we report the X-ray structure of the ternary complex between staphylococcal enterotoxin H (SEH) and its human receptors, MHC class II and TCR. The structure demonstrates that SEH predominantly interacts with the variable alpha-domain of TCR (TCRValpha), which is supported by nuclear magnetic resonance (NMR) analyses. Furthermore, there is no contact between MHC and TCR upon complex formation. Structural analyses suggest that the major contact points to TCRValpha are conserved among other bacterial SAgs. Consequently, a new dimension of SAg biology emerges, suggesting that in addition to the conventional interactions with the TCRVbeta domain, SAgs can also activate T cells through the TCRValpha domain.

The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation.,Saline M, Rodstrom KE, Fischer G, Orekhov VY, Karlsson BG, Lindkvist-Petersson K Nat Commun. 2010 Nov 16;1:119. PMID:21081917^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Saline M, Rodstrom KE, Fischer G, Orekhov VY, Karlsson BG, Lindkvist-Petersson K. The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation. Nat Commun. 2010 Nov 16;1:119. PMID:21081917 doi:10.1038/ncomms1117

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2xna"

@@ Line 1: / Line 1: @@
 ==Crystal structure of the complex between human T cell receptor and staphylococcal enterotoxin==
-<StructureSection load='2xna' size='340' side='right' caption='[[2xna]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+<StructureSection load='2xna' size='340' side='right'caption='[[2xna]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2xna]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XNA FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2xna]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XNA FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1enf|1enf]], [[2esv|2esv]], [[1f77|1f77]], [[1qrn|1qrn]], [[1kgc|1kgc]], [[2bnr|2bnr]], [[2ak4|2ak4]], [[2gj6|2gj6]], [[2cdg|2cdg]], [[2bnu|2bnu]], [[2eys|2eys]], [[1mi5|1mi5]], [[2cdf|2cdf]], [[1fyt|1fyt]], [[1ymm|1ymm]], [[1ewc|1ewc]], [[1j8h|1j8h]], [[1zgl|1zgl]], [[2axh|2axh]], [[1ktk|1ktk]], [[2eyt|2eyt]], [[2bnq|2bnq]], [[1oga|1oga]], [[2eyr|2eyr]], [[2cde|2cde]], [[2xn9|2xn9]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xna OCA], [http://pdbe.org/2xna PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xna RCSB], [http://www.ebi.ac.uk/pdbsum/2xna PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xna ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xna OCA], [http://pdbe.org/2xna PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xna RCSB], [http://www.ebi.ac.uk/pdbsum/2xna PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xna ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 22: / Line 22: @@
 ==See Also==
 *[[T-cell receptor|T-cell receptor]]
+*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
 == References ==
 <references/>
@@ Line 27: / Line 28: @@
 </StructureSection>
 [[Category: Human]]
+[[Category: Large Structures]]
 [[Category: Fischer, G]]
 [[Category: Karlsson, B G]]

2xna

From Proteopedia

Revision as of 12:13, 22 July 2020

Crystal structure of the complex between human T cell receptor and staphylococcal enterotoxin

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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