2xyk

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(Difference between revisions)

Revision as of 12:26, 22 July 2020

Group II 2-on-2 Hemoglobin from the Plant Pathogen Agrobacterium tumefaciens

Structural highlights

2xyk is a 2 chain structure with sequence from "achromobacter_radiobacter"_(beijerinck_and_van_delden_1902)_bergey_et_al._1934 "achromobacter radiobacter" (beijerinck and van delden 1902) bergey et al. 1934. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

Within the 2/2 hemoglobin sub-family, no group II 2/2Hbs from proteobacteria have been so far studied. Here we present the first structural characterization of a group II 2/2Hb from the soil and phytopathogenic bacterium Agrobacterium tumefaciens (At-2/2HbO). The crystal structure of ferric At-2/2HbO (reported at 2.1A resolution) shows the location of specific/unique heme distal site residues (e.g., His(42)CD1, a residue distinctive of proteobacteria group II 2/2Hbs) that surround a heme-liganded water molecule. A highly intertwined hydrogen-bonded network, involving residues Tyr(26)B10, His(42)CD1, Ser(49)E7, Trp(93)G8, and three distal site water molecules, stabilizes the heme-bound ligand. Such a structural organization suggests a path for diatomic ligand diffusion to/from the heme. Neither a similar distal site structuring effect nor the presence of distal site water molecules has been so far observed in group I and group III 2/2Hbs, thus adding new distinctive information to the complex picture of currently available 2/2Hb structural and functional data.

Structural characterization of a group II 2/2 hemoglobin from the plant pathogen Agrobacterium tumefaciens.,Pesce A, Nardini M, Labarre M, Richard C, Wittenberg JB, Wittenberg BA, Guertin M, Bolognesi M Biochim Biophys Acta. 2010 Nov 9. PMID:21070893^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Pesce A, Nardini M, Labarre M, Richard C, Wittenberg JB, Wittenberg BA, Guertin M, Bolognesi M. Structural characterization of a group II 2/2 hemoglobin from the plant pathogen Agrobacterium tumefaciens. Biochim Biophys Acta. 2010 Nov 9. PMID:21070893 doi:10.1016/j.bbapap.2010.11.001

1 Structural highlights
2 Publication Abstract from PubMed
3 See Also
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2xyk"

@@ Line 1: / Line 1: @@
 ==Group II 2-on-2 Hemoglobin from the Plant Pathogen Agrobacterium tumefaciens==
-<StructureSection load='2xyk' size='340' side='right' caption='[[2xyk]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+<StructureSection load='2xyk' size='340' side='right'caption='[[2xyk]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2xyk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"achromobacter_radiobacter"_(beijerinck_and_van_delden_1902)_bergey_et_al._1934 "achromobacter radiobacter" (beijerinck and van delden 1902) bergey et al. 1934]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XYK FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2xyk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"achromobacter_radiobacter"_(beijerinck_and_van_delden_1902)_bergey_et_al._1934 "achromobacter radiobacter" (beijerinck and van delden 1902) bergey et al. 1934]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XYK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XYK FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xyk OCA], [http://pdbe.org/2xyk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xyk RCSB], [http://www.ebi.ac.uk/pdbsum/2xyk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xyk ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xyk OCA], [http://pdbe.org/2xyk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xyk RCSB], [http://www.ebi.ac.uk/pdbsum/2xyk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xyk ProSAT]</span></td></tr>
 </table>
 <div style="background-color:#fffaf0;">
@@ Line 23: / Line 23: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Bolognesi, M]]
 [[Category: Guertin, M]]

2xyk

From Proteopedia

Revision as of 12:26, 22 July 2020

Group II 2-on-2 Hemoglobin from the Plant Pathogen Agrobacterium tumefaciens

Structural highlights

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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