1c8o
From Proteopedia
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'''2.9 A STRUCTURE OF CLEAVED VIRAL SERPIN CRMA''' | '''2.9 A STRUCTURE OF CLEAVED VIRAL SERPIN CRMA''' | ||
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[[Category: Simonovic, M.]] | [[Category: Simonovic, M.]] | ||
[[Category: Volz, K.]] | [[Category: Volz, K.]] | ||
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Revision as of 09:28, 2 May 2008
2.9 A STRUCTURE OF CLEAVED VIRAL SERPIN CRMA
Overview
CrmA is an unusual viral serpin that inhibits both cysteine and serine proteinases involved in the regulation of host inflammatory and apoptosis processes. It differs from other members of the serpin superfamily by having a reactive center loop that is one residue shorter, and by its apparent inability to form SDS-stable covalent complexes with cysteine proteinases. To obtain insight into the inhibitory mechanism of crmA, we determined the crystal structure of reactive center loop-cleaved crmA to 2.9 A resolution. The structure, which is the first of a viral serpin, suggests that crmA can inhibit cysteine proteinases by a mechanism analogous to that used by other serpins against serine proteinases. However, one striking difference from other serpins, which may be significant for in vivo function, is an additional highly charged antiparallel strand for b sheet A, whose sequence and length are unique to crmA.
About this Structure
1C8O is a Protein complex structure of sequences from Cowpox virus. Full crystallographic information is available from OCA.
Reference
Crystal structure of viral serpin crmA provides insights into its mechanism of cysteine proteinase inhibition., Simonovic M, Gettins PGW, Volz K, Protein Sci. 2000 Aug;9(8):1423-7. PMID:10975564 Page seeded by OCA on Fri May 2 12:27:57 2008
