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Furin

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== Relevance ==
== Relevance ==
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High furin activity promotes the malignant phenotype of cancer cells in head and neck squamous cell carcinoma, breast cancer and <ref>PMID:28369813</ref>. Furin has a role in atherosclerosis<ref>PMID:28400053</ref>. The new coronavirus SARS-CoV19 genome sequence shows a furin-like cleavage site in the spike protein. This cleavage site has potential implications in the development of antivirals<ref>PMID:32057769</ref>.
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High furin activity promotes the malignant phenotype of cancer cells in head and neck squamous cell carcinoma, breast cancer and <ref>PMID:28369813</ref>. Furin has a role in atherosclerosis<ref>PMID:28400053</ref>. The new coronavirus SARS-CoV19 genome sequence shows a furin-like cleavage site in the spike protein. This cleavage site has potential implications in the development of antivirals<ref>PMID:32057769</ref>. See [[SARS-CoV-2 protein S priming by furin]], an animation.
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== Structural highlights ==
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<!--== Structural highlights == -->
</StructureSection>
</StructureSection>

Revision as of 21:51, 27 July 2020

Human furin complex with peptide inhibitor, Ca++ (green), Na+ (purple), citrulline, phenylacetaldehyde and aminoetyl-benzenecarboximiidamide (PDB 6eqv)

Drag the structure with the mouse to rotate

3D structures of furin

Updated on 27-July-2020

5jxg, 5jxi - hFur - human
4z2a - hFur (mutant)
6eqx, 6eqw, 6eqv, 5jxh, 5jxj, 6hlb, 6hld, 6hle, 6hza, 6hzb, 6hzc, 6hzd, 4ryd, 4omc, 5omd - hFur + peptide inhibitor
5mim - hFur + inhibitor
5jmo - hFur + antibody
1p8j - mFur + peptide inhibitor - mouse


References

  1. ↑ Thomas G. Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol. 2002 Oct;3(10):753-66. doi: 10.1038/nrm934. PMID:12360192 doi:http://dx.doi.org/10.1038/nrm934
  2. ↑ Jaaks P, Bernasconi M. The proprotein convertase furin in tumour progression. Int J Cancer. 2017 Aug 15;141(4):654-663. doi: 10.1002/ijc.30714. Epub 2017 May, 15. PMID:28369813 doi:http://dx.doi.org/10.1002/ijc.30714
  3. ↑ Ren K, Jiang T, Zheng XL, Zhao GJ. Proprotein convertase furin/PCSK3 and atherosclerosis: New insights and potential therapeutic targets. Atherosclerosis. 2017 Jul;262:163-170. doi:, 10.1016/j.atherosclerosis.2017.04.005. Epub 2017 Apr 7. PMID:28400053 doi:http://dx.doi.org/10.1016/j.atherosclerosis.2017.04.005
  4. ↑ Coutard B, Valle C, de Lamballerie X, Canard B, Seidah NG, Decroly E. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Res. 2020 Apr;176:104742. doi: 10.1016/j.antiviral.2020.104742. Epub, 2020 Feb 10. PMID:32057769 doi:http://dx.doi.org/10.1016/j.antiviral.2020.104742

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Eric Martz

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