1c9h

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[[Image:1c9h.gif|left|200px]]
[[Image:1c9h.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1c9h |SIZE=350|CAPTION= <scene name='initialview01'>1c9h</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1c9h", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= CDNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1c9h| PDB=1c9h | SCENE= }}
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|RELATEDENTRY=[[1fkl|1FKL]], [[1fap|1FAP]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c9h OCA], [http://www.ebi.ac.uk/pdbsum/1c9h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1c9h RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF FKBP12.6 IN COMPLEX WITH RAPAMYCIN'''
'''CRYSTAL STRUCTURE OF FKBP12.6 IN COMPLEX WITH RAPAMYCIN'''
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[[Category: Narayana, S V.L.]]
[[Category: Narayana, S V.L.]]
[[Category: Thotakura, A.]]
[[Category: Thotakura, A.]]
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[[Category: complex]]
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[[Category: Complex]]
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[[Category: fkbp12]]
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[[Category: Fkbp12]]
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[[Category: rapamycin]]
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[[Category: Rapamycin]]
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[[Category: ryanodine receptor]]
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[[Category: Ryanodine receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:29:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:17:18 2008''
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Revision as of 09:29, 2 May 2008

Image:1c9h.gif

Template:STRUCTURE 1c9h

CRYSTAL STRUCTURE OF FKBP12.6 IN COMPLEX WITH RAPAMYCIN


Overview

FKBP12.6 is a novel isoform of FKBP12, which selectively binds to the cardiac ryanodine receptor (RyR2). The crystal structure of FKBP12.6 in complex with rapamycin has now been determined at 2.0 A resolution. The structures of FKBP12.6 and FKBP12 are nearly identical, except for a displacement observed in the helical region of FKBP12.6 toward the hydrophobic pocket. This displacement was not predicted by homology modeling studies. Analyses of the residues that are likely to confer the RyR2-binding specificity are presented.

About this Structure

1C9H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of FKBP12.6 in complex with rapamycin., Deivanayagam CC, Carson M, Thotakura A, Narayana SV, Chodavarapu RS, Acta Crystallogr D Biol Crystallogr. 2000 Mar;56(Pt 3):266-71. PMID:10713512 Page seeded by OCA on Fri May 2 12:29:39 2008

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