1uup

From Proteopedia

(Difference between revisions)

Revision as of 11:49, 29 July 2020

Crystal Structure of A Dimeric Form of Streptococcal Pyrogenic Exotoxin A (SpeA1).

Structural highlights

1uup is a 4 chain structure with sequence from "micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	1b1z, 1fnu, 1fnv, 1fnw, 1ha5, 1l0x, 1l0y
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SPEA_STRPY] Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Streptococcal pyrogenic exotoxin A (SpeA1) is a bacterial superantigen associated with scarlet fever and streptococcal toxic shock syndrome (STSS). SpeA1 is found in both monomeric and dimeric forms, and previous work suggested that the dimer results from an intermolecular disulfide bond between the cysteines at positions 90 of each monomer. Here, we present the crystal structure of the dimeric form of SpeA1. The toxin crystallizes in the orthorhombic space group P212121, with two dimers in the crystallographic asymmetric unit. The final structure has a crystallographic R-factor of 21.52% for 7248 protein atoms, 136 water molecules, and 4 zinc atoms (one zinc atom per molecule). The implications of SpeA1 dimer on MHC class II and T-cell receptor recognition are discussed.

Crystal structure of a dimeric form of streptococcal pyrogenic exotoxin A (SpeA1).,Baker MD, Gendlina I, Collins CM, Acharya KR Protein Sci. 2004 Sep;13(9):2285-90. Epub 2004 Aug 4. PMID:15295110^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Baker MD, Gendlina I, Collins CM, Acharya KR. Crystal structure of a dimeric form of streptococcal pyrogenic exotoxin A (SpeA1). Protein Sci. 2004 Sep;13(9):2285-90. Epub 2004 Aug 4. PMID:15295110 doi:10.1110/ps.04826804

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1uup"

@@ Line 1: / Line 1: @@
 ==Crystal Structure of A Dimeric Form of Streptococcal Pyrogenic Exotoxin A (SpeA1).==
-<StructureSection load='1uup' size='340' side='right' caption='[[1uup]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+<StructureSection load='1uup' size='340' side='right'caption='[[1uup]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1uup]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UUP FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1uup]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UUP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1UUP FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1b1z|1b1z]], [[1fnu|1fnu]], [[1fnv|1fnv]], [[1fnw|1fnw]], [[1ha5|1ha5]], [[1l0x|1l0x]], [[1l0y|1l0y]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uup OCA], [http://pdbe.org/1uup PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uup RCSB], [http://www.ebi.ac.uk/pdbsum/1uup PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uup ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1uup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uup OCA], [http://pdbe.org/1uup PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uup RCSB], [http://www.ebi.ac.uk/pdbsum/1uup PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uup ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 31: / Line 31: @@
 ==See Also==
-*[[Exotoxin|Exotoxin]]
+*[[Exotoxin 3D structures|Exotoxin 3D structures]]
 == References ==
 <references/>
@@ Line 37: / Line 37: @@
 </StructureSection>
 [[Category: Micrococcus scarlatinae klein 1884]]
+[[Category: Large Structures]]
 [[Category: Acharya, K R]]
 [[Category: Baker, M D]]

1uup

From Proteopedia

Revision as of 11:49, 29 July 2020

Crystal Structure of A Dimeric Form of Streptococcal Pyrogenic Exotoxin A (SpeA1).

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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