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3ak9

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Revision as of 12:23, 29 July 2020

Crystal structure of the SEp22 dodecamer, a Dps-like protein from Salmonella enterica subsp. enterica serovar Enteritidis, FE-soaked form

Structural highlights

3ak9 is a 12 chain structure with sequence from Salmonella enterica subsp. enterica serovar kentucky cvm29188. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Related:	3ak8
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[B3YEF4_SALET] During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction.[HAMAP-Rule:MF_01441]

Publication Abstract from PubMed

The crystal structure of SEp22, a DNA-binding protein from starved cells from Salmonella enterica subsp. enterica serovar Enteritidis, has been determined in two forms: the native state at 1.25 A resolution and an iron-soaked form at 1.30 A resolution. The SEp22 protomers form a dodecameric shell with 23 symmetry and a single iron ion per protomer was found at the ferroxidase centre in the iron-soaked form. Along the threefold axes of the 23 symmetry, hydrophilic Asp channels that consist of Asp146 were found. Iron ions may flow into the cavity of the dodecameric shell through the Asp channels.

Structures of the SEp22 dodecamer, a Dps-like protein from Salmonella enterica subsp. enterica serovar Enteritidis.,Miyamoto T, Asahina Y, Miyazaki S, Shimizu H, Ohto U, Noguchi S, Satow Y Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jan 1;67(Pt, 1):17-22. Epub 2010 Dec 21. PMID:21206015^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Miyamoto T, Asahina Y, Miyazaki S, Shimizu H, Ohto U, Noguchi S, Satow Y. Structures of the SEp22 dodecamer, a Dps-like protein from Salmonella enterica subsp. enterica serovar Enteritidis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jan 1;67(Pt, 1):17-22. Epub 2010 Dec 21. PMID:21206015 doi:10.1107/S1744309110043113

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ak9"

@@ Line 1: / Line 1: @@
 ==Crystal structure of the SEp22 dodecamer, a Dps-like protein from Salmonella enterica subsp. enterica serovar Enteritidis, FE-soaked form==
-<StructureSection load='3ak9' size='340' side='right' caption='[[3ak9]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
+<StructureSection load='3ak9' size='340' side='right'caption='[[3ak9]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3ak9]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_kentucky_cvm29188 Salmonella enterica subsp. enterica serovar kentucky cvm29188]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AK9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3ak9]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_kentucky_cvm29188 Salmonella enterica subsp. enterica serovar kentucky cvm29188]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AK9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3AK9 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ak8|3ak8]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ak9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ak9 OCA], [http://pdbe.org/3ak9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ak9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ak9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ak9 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3ak9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ak9 OCA], [http://pdbe.org/3ak9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ak9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ak9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ak9 ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 21: / Line 21: @@
 ==See Also==
-*[[Ferritin|Ferritin]]
+*[[Ferritin 3D structures|Ferritin 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Salmonella enterica subsp. enterica serovar kentucky cvm29188]]
 [[Category: Asahina, Y]]

3ak9

From Proteopedia

Revision as of 12:23, 29 July 2020

Crystal structure of the SEp22 dodecamer, a Dps-like protein from Salmonella enterica subsp. enterica serovar Enteritidis, FE-soaked form

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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