6via
From Proteopedia
(Difference between revisions)
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==Observing a ring-cleaving dioxygenase in action through a crystalline lens - a seven-membered lactone bound structure== | ==Observing a ring-cleaving dioxygenase in action through a crystalline lens - a seven-membered lactone bound structure== | ||
| - | <StructureSection load='6via' size='340' side='right'caption='[[6via]]' scene=''> | + | <StructureSection load='6via' size='340' side='right'caption='[[6via]], [[Resolution|resolution]] 1.59Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VIA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VIA FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6via]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cupmc Cupmc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VIA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VIA FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6via FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6via OCA], [http://pdbe.org/6via PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6via RCSB], [http://www.ebi.ac.uk/pdbsum/6via PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6via ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EAY:(2R,3E)-2-hydroxy-3-imino-2,3-dihydrooxepine-4-carboxylic+acid'>EAY</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nbaC, Rmet_5193 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=266264 CUPMC])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxyanthranilate_3,4-dioxygenase 3-hydroxyanthranilate 3,4-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.6 1.13.11.6] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6via FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6via OCA], [http://pdbe.org/6via PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6via RCSB], [http://www.ebi.ac.uk/pdbsum/6via PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6via ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/3HAO_CUPMC 3HAO_CUPMC]] Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.[HAMAP-Rule:MF_00825]<ref>PMID:15909977</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: 3-hydroxyanthranilate 3,4-dioxygenase]] | ||
| + | [[Category: Cupmc]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Liu A]] | + | [[Category: Liu, A]] |
| - | [[Category: Liu F]] | + | [[Category: Liu, F]] |
| - | [[Category: Wang Y]] | + | [[Category: Wang, Y]] |
| - | [[Category: Yang Y]] | + | [[Category: Yang, Y]] |
| + | [[Category: Extradiol dioxygenase]] | ||
| + | [[Category: In crystallo reaction]] | ||
| + | [[Category: Intermediate]] | ||
| + | [[Category: Nad+ biosynthesis]] | ||
| + | [[Category: Oxidoreductase]] | ||
Revision as of 05:56, 5 August 2020
Observing a ring-cleaving dioxygenase in action through a crystalline lens - a seven-membered lactone bound structure
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