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6wuw
From Proteopedia
(Difference between revisions)
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==Crystal structure of Human Serum Albumin complex with JMS-053== | ==Crystal structure of Human Serum Albumin complex with JMS-053== | ||
| - | <StructureSection load='6wuw' size='340' side='right'caption='[[6wuw]]' scene=''> | + | <StructureSection load='6wuw' size='340' side='right'caption='[[6wuw]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WUW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WUW FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6wuw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WUW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6WUW FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wuw OCA], [http://pdbe.org/6wuw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wuw RCSB], [http://www.ebi.ac.uk/pdbsum/6wuw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wuw ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=OCA:OCTANOIC+ACID+(CAPRYLIC+ACID)'>OCA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=UAY:7-imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione'>UAY</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6wuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wuw OCA], [http://pdbe.org/6wuw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6wuw RCSB], [http://www.ebi.ac.uk/pdbsum/6wuw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6wuw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Albumin 3D structures|Albumin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Cooper | + | [[Category: Structural genomic]] |
| - | [[Category: Czub | + | [[Category: Cooper, D R]] |
| - | [[Category: Lazo | + | [[Category: Czub, M P]] |
| - | [[Category: Minor W]] | + | [[Category: Lazo, J S]] |
| - | [[Category: Shabalin | + | [[Category: Minor, W]] |
| + | [[Category: Shabalin, I G]] | ||
| + | [[Category: Albumin]] | ||
| + | [[Category: Csgid]] | ||
| + | [[Category: Drug transport]] | ||
| + | [[Category: Hsa]] | ||
| + | [[Category: Jms-053]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 05:58, 5 August 2020
Crystal structure of Human Serum Albumin complex with JMS-053
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Categories: Homo sapiens | Large Structures | Structural genomic | Cooper, D R | Czub, M P | Lazo, J S | Minor, W | Shabalin, I G | Albumin | Csgid | Drug transport | Hsa | Jms-053 | Transport protein
