This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

3bh0

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Revision as of 06:17, 5 August 2020

ATPase Domain of G40P

Structural highlights

3bh0 is a 1 chain structure with sequence from Bpspp. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	3bgw
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Helicases are essential enzymes for DNA replication, a fundamental process in all living organisms. The DnaB family are hexameric replicative helicases that unwind duplex DNA and coordinate with RNA primase and other proteins at the replication fork in prokaryotes. Here, we report the full-length crystal structure of G40P, a DnaB family helicase. The hexamer complex reveals an unusual architectural feature and a new type of assembly mechanism. The hexamer has two tiers: a three-fold symmetric N-terminal tier and a six-fold symmetric C-terminal tier. Monomers with two different conformations, termed cis and trans, come together to provide a topological solution for the dual symmetry within a hexamer. Structure-guided mutational studies indicate an important role for the N-terminal tier in binding primase and regulating primase-mediated stimulation of helicase activity. This study provides insights into the structural and functional interplay between G40P helicase and DnaG primase.

The structure of a DnaB-family replicative helicase and its interactions with primase.,Wang G, Klein MG, Tokonzaba E, Zhang Y, Holden LG, Chen XS Nat Struct Mol Biol. 2008 Jan;15(1):94-100. Epub 2007 Dec 23. PMID:18157148^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Wang G, Klein MG, Tokonzaba E, Zhang Y, Holden LG, Chen XS. The structure of a DnaB-family replicative helicase and its interactions with primase. Nat Struct Mol Biol. 2008 Jan;15(1):94-100. Epub 2007 Dec 23. PMID:18157148 doi:10.1038/nsmb1356

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3bh0"

@@ Line 1: / Line 1: @@
 ==ATPase Domain of G40P==
-<StructureSection load='3bh0' size='340' side='right' caption='[[3bh0]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
+<StructureSection load='3bh0' size='340' side='right'caption='[[3bh0]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3bh0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpspp Bpspp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BH0 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3bh0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpspp Bpspp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BH0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3BH0 FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bgw|3bgw]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bh0 OCA], [http://pdbe.org/3bh0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bh0 RCSB], [http://www.ebi.ac.uk/pdbsum/3bh0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bh0 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3bh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bh0 OCA], [http://pdbe.org/3bh0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bh0 RCSB], [http://www.ebi.ac.uk/pdbsum/3bh0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bh0 ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==
@@ Line 28: / Line 28: @@
 ==See Also==
-*[[Helicase|Helicase]]
+*[[Helicase 3D structures|Helicase 3D structures]]
 == References ==
 <references/>
@@ Line 34: / Line 34: @@
 </StructureSection>
 [[Category: Bpspp]]
+[[Category: Large Structures]]
 [[Category: Chen, X S]]
 [[Category: Holden, L G]]

3bh0

From Proteopedia

Revision as of 06:17, 5 August 2020

ATPase Domain of G40P

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox