5kxa

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==Selective Inhibition of Autotaxin is Effective in Mouse Models of Liver Fibrosis==
==Selective Inhibition of Autotaxin is Effective in Mouse Models of Liver Fibrosis==
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<StructureSection load='5kxa' size='340' side='right' caption='[[5kxa]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
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<StructureSection load='5kxa' size='340' side='right'caption='[[5kxa]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5kxa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KXA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KXA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5kxa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KXA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5KXA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6Y7:3-[6-CHLORANYL-2-CYCLOPROPYL-1-(1-ETHYLPYRAZOL-4-YL)-7-FLUORANYL-INDOL-3-YL]SULFANYL-2-FLUORANYL-BENZOIC+ACID'>6Y7</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6Y7:3-[6-CHLORANYL-2-CYCLOPROPYL-1-(1-ETHYLPYRAZOL-4-YL)-7-FLUORANYL-INDOL-3-YL]SULFANYL-2-FLUORANYL-BENZOIC+ACID'>6Y7</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zg7|4zg7]], [[4zg6|4zg6]], [[4zg9|4zg9]], [[4zga|4zga]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zg7|4zg7]], [[4zg6|4zg6]], [[4zg9|4zg9]], [[4zga|4zga]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ENPP2, ATX, PDNP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylglycerophosphoethanolamine_phosphodiesterase Alkylglycerophosphoethanolamine phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.39 3.1.4.39] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylglycerophosphoethanolamine_phosphodiesterase Alkylglycerophosphoethanolamine phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.39 3.1.4.39] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kxa OCA], [http://pdbe.org/5kxa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kxa RCSB], [http://www.ebi.ac.uk/pdbsum/5kxa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kxa ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5kxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kxa OCA], [http://pdbe.org/5kxa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kxa RCSB], [http://www.ebi.ac.uk/pdbsum/5kxa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kxa ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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</div>
</div>
<div class="pdbe-citations 5kxa" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5kxa" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ectonucleotide pyrophosphatase/phosphodiesterase 3D structures|Ectonucleotide pyrophosphatase/phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Alkylglycerophosphoethanolamine phosphodiesterase]]
[[Category: Alkylglycerophosphoethanolamine phosphodiesterase]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Bain, G]]
[[Category: Bain, G]]
[[Category: Evans, J F]]
[[Category: Evans, J F]]

Revision as of 06:36, 5 August 2020

Selective Inhibition of Autotaxin is Effective in Mouse Models of Liver Fibrosis

PDB ID 5kxa

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