1cd1

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[[Image:1cd1.gif|left|200px]]
[[Image:1cd1.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1cd1", creates the "Structure Box" on the page.
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|SITE=
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|GENE= CD1.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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{{STRUCTURE_1cd1| PDB=1cd1 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cd1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cd1 OCA], [http://www.ebi.ac.uk/pdbsum/1cd1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cd1 RCSB]</span>
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'''CD1(MOUSE) ANTIGEN PRESENTING MOLECULE'''
'''CD1(MOUSE) ANTIGEN PRESENTING MOLECULE'''
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[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
[[Category: Zeng, Z H.]]
[[Category: Zeng, Z H.]]
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[[Category: cd1]]
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[[Category: Cd1]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: immunoglobulin fold]]
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[[Category: Immunoglobulin fold]]
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[[Category: immunology]]
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[[Category: Immunology]]
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[[Category: mhc]]
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[[Category: Mhc]]
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[[Category: signal]]
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[[Category: Signal]]
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[[Category: t-cell]]
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[[Category: T-cell]]
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[[Category: tcr]]
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[[Category: Tcr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:35:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:19:17 2008''
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Revision as of 09:35, 2 May 2008

Image:1cd1.gif

Template:STRUCTURE 1cd1

CD1(MOUSE) ANTIGEN PRESENTING MOLECULE


Overview

CD1 represents a third lineage of antigen-presenting molecules that are distantly related to major histocompatibility complex (MHC) molecules in the immune system. The crystal structure of mouse CD1d1, corresponding to human CD1d, at 2.8 resolution shows that CD1 adopts an MHC fold that is more closely related to that of MHC class I than to that of MHC class II. The binding groove, although significantly narrower, is substantially larger because of increased depth and it has only two major pockets that are almost completely hydrophobic. The extreme hydrophobicity and shape of the binding site are consistent with observations that human CD1b and CD1c can present mycobacterial cell wall antigens, such as mycolic acid and lipoarabinomannans. However, mouse CD1d1 can present very hydrophobic peptides, but must do so in a very different way from MHC class Ia and class II molecules.

About this Structure

1CD1 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove., Zeng Z, Castano AR, Segelke BW, Stura EA, Peterson PA, Wilson IA, Science. 1997 Jul 18;277(5324):339-45. PMID:9219685 Page seeded by OCA on Fri May 2 12:35:48 2008

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