1cdt

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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cdt OCA], [http://www.ebi.ac.uk/pdbsum/1cdt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cdt RCSB]</span>
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'''CARDIOTOXIN V4/II FROM NAJA MOSSAMBICA MOSSAMBICA: THE REFINED CRYSTAL STRUCTURE'''
'''CARDIOTOXIN V4/II FROM NAJA MOSSAMBICA MOSSAMBICA: THE REFINED CRYSTAL STRUCTURE'''
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[[Category: Rees, B.]]
[[Category: Rees, B.]]
[[Category: Samama, J P.]]
[[Category: Samama, J P.]]
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[[Category: cytotoxin]]
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[[Category: Cytotoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:37:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:19:43 2008''
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Revision as of 09:37, 2 May 2008

Image:1cdt.jpg

Template:STRUCTURE 1cdt

CARDIOTOXIN V4/II FROM NAJA MOSSAMBICA MOSSAMBICA: THE REFINED CRYSTAL STRUCTURE


Overview

The crystal structure of cardiotoxin VII4 from Naja mossambica mossambica was refined to 2.5 A resolution. Fifty ordered solvent sites were localized and included in the refinement. The final R factor is 0.197 (lambda/(2sin theta) less than 5 A; F greater than 3 sigma). The three-dimensional structure is characterized by two beta-sheets. Of particular interest is the two-stranded beta-sheet in the N-terminal region. This shows a large right-handed twist and, though strongly connected to the core of the molecule, and in particular to the C-terminal end, protrudes out of the bulk of the molecule. The segment of four amino acid residues connecting the two strands of this sheet is particularly exposed. It contains an invariant proline residue that has probably an important structural role, and is completely hydrophobic. Two other conserved hydrophobic zones were identified; the largest extends over the second and third loops, on one side only of the molecule. All side-chains of invariant hydrophobic character (except proline residues) belong to one of these three zones. Also discussed are the dimeric assembly and the rather loose packing in the crystal. The three-dimensional structure is compared with that of short and long alpha-neurotoxins. Comparison with two-dimensional nuclear magnetic resonance results on the 68% homologous cardiotoxin CT X IIb shows an excellent overall agreement. A few differences are probably genuine.

About this Structure

1CDT is a Single protein structure of sequence from Naja mossambica. Full crystallographic information is available from OCA.

Reference

Cardiotoxin VII4 from Naja mossambica mossambica. The refined crystal structure., Rees B, Bilwes A, Samama JP, Moras D, J Mol Biol. 1990 Jul 5;214(1):281-97. PMID:2370666 Page seeded by OCA on Fri May 2 12:37:08 2008

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