5lia

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==Crystal structure of murine autotaxin in complex with a small molecule inhibitor==
==Crystal structure of murine autotaxin in complex with a small molecule inhibitor==
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<StructureSection load='5lia' size='340' side='right' caption='[[5lia]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
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<StructureSection load='5lia' size='340' side='right'caption='[[5lia]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lia]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LIA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lia]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LIA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LIA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6XN:~{N}-[(1~{S})-1-(4-CHLOROPHENYL)ETHYL]-3-[3-[[4-(TRIFLUOROMETHYLOXY)PHENYL]METHYL]IMIDAZO[4,5-B]PYRIDIN-2-YL]PROPANAMIDE'>6XN</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6XN:~{N}-[(1~{S})-1-(4-CHLOROPHENYL)ETHYL]-3-[3-[[4-(TRIFLUOROMETHYLOXY)PHENYL]METHYL]IMIDAZO[4,5-B]PYRIDIN-2-YL]PROPANAMIDE'>6XN</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Enpp2, Npps2, Pdnp2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylglycerophosphoethanolamine_phosphodiesterase Alkylglycerophosphoethanolamine phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.39 3.1.4.39] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylglycerophosphoethanolamine_phosphodiesterase Alkylglycerophosphoethanolamine phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.39 3.1.4.39] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lia OCA], [http://pdbe.org/5lia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lia RCSB], [http://www.ebi.ac.uk/pdbsum/5lia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lia ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lia OCA], [http://pdbe.org/5lia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lia RCSB], [http://www.ebi.ac.uk/pdbsum/5lia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lia ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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</div>
</div>
<div class="pdbe-citations 5lia" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5lia" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ectonucleotide pyrophosphatase/phosphodiesterase 3D structures|Ectonucleotide pyrophosphatase/phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Alkylglycerophosphoethanolamine phosphodiesterase]]
[[Category: Alkylglycerophosphoethanolamine phosphodiesterase]]
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[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
[[Category: Cheasty, A]]
[[Category: Cheasty, A]]
[[Category: Owen, P]]
[[Category: Owen, P]]

Revision as of 10:38, 12 August 2020

Crystal structure of murine autotaxin in complex with a small molecule inhibitor

PDB ID 5lia

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