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5ln2

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==Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument==
==Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument==
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<StructureSection load='5ln2' size='340' side='right' caption='[[5ln2]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
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<StructureSection load='5ln2' size='340' side='right'caption='[[5ln2]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ln2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LN2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ln2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LN2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LN2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6ZT:(4~{S})-5-[5-CHLORANYL-2-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]-4-(4-CHLORANYL-2-METHYL-PHENYL)-2-(2-METHOXYPHENYL)-3-PROPAN-2-YL-4~{H}-PYRROLO[3,4-C]PYRAZOL-6-ONE'>6ZT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6ZT:(4~{S})-5-[5-CHLORANYL-2-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]-4-(4-CHLORANYL-2-METHYL-PHENYL)-2-(2-METHOXYPHENYL)-3-PROPAN-2-YL-4~{H}-PYRROLO[3,4-C]PYRAZOL-6-ONE'>6ZT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ln2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ln2 OCA], [http://pdbe.org/5ln2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ln2 RCSB], [http://www.ebi.ac.uk/pdbsum/5ln2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ln2 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MDM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ln2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ln2 OCA], [http://pdbe.org/5ln2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ln2 RCSB], [http://www.ebi.ac.uk/pdbsum/5ln2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ln2 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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</div>
</div>
<div class="pdbe-citations 5ln2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ln2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[MDM2 3D structures|MDM2 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Kallen, J]]
[[Category: Kallen, J]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]
[[Category: Inhibitor complex]]
[[Category: Inhibitor complex]]
[[Category: Ppi with p53]]
[[Category: Ppi with p53]]

Revision as of 10:42, 12 August 2020

Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument

PDB ID 5ln2

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