5lpk

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==Crystal structure of the bromodomain of human EP300 bound to the inhibitor XDM1==
==Crystal structure of the bromodomain of human EP300 bound to the inhibitor XDM1==
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<StructureSection load='5lpk' size='340' side='right' caption='[[5lpk]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='5lpk' size='340' side='right'caption='[[5lpk]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5lpk]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LPK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LPK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5lpk]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LPK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LPK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XDM:~{N}-[(3-chlorophenyl)methyl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide'>XDM</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XDM:~{N}-[(3-chlorophenyl)methyl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide'>XDM</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5nrw|5nrw]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5nrw|5nrw]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lpk OCA], [http://pdbe.org/5lpk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lpk RCSB], [http://www.ebi.ac.uk/pdbsum/5lpk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lpk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lpk OCA], [http://pdbe.org/5lpk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lpk RCSB], [http://www.ebi.ac.uk/pdbsum/5lpk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lpk ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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</div>
</div>
<div class="pdbe-citations 5lpk" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5lpk" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Histone acetyltransferase]]
[[Category: Histone acetyltransferase]]
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[[Category: Large Structures]]
[[Category: Huegle, M]]
[[Category: Huegle, M]]
[[Category: Wohlwend, D]]
[[Category: Wohlwend, D]]

Revision as of 10:45, 12 August 2020

Crystal structure of the bromodomain of human EP300 bound to the inhibitor XDM1

PDB ID 5lpk

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