6knr
From Proteopedia
(Difference between revisions)
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==Crystal structure of Estrogen-related receptor gamma ligand-binding domain with DN200699== | ==Crystal structure of Estrogen-related receptor gamma ligand-binding domain with DN200699== | ||
| - | <StructureSection load='6knr' size='340' side='right'caption='[[6knr]]' scene=''> | + | <StructureSection load='6knr' size='340' side='right'caption='[[6knr]], [[Resolution|resolution]] 2.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KNR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KNR FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6knr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KNR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KNR FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6knr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6knr OCA], [http://pdbe.org/6knr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6knr RCSB], [http://www.ebi.ac.uk/pdbsum/6knr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6knr ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DL9:(E)-4-(1-(4-(1-cyclopropylpiperidin-4-yl)phenyl)-5-hydroxy-2-phenylpent-1-en-1-yl)phenol'>DL9</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ESRRG, ERR3, ERRG2, KIAA0832, NR3B3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6knr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6knr OCA], [http://pdbe.org/6knr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6knr RCSB], [http://www.ebi.ac.uk/pdbsum/6knr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6knr ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN]] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Estrogen-related receptor gamma (ERRgamma) is the NR3B subgroup of associated transcription factors. In this report, a new generation of a potent and selective ERRgamma inverse agonist (25) with good biocompatibility was proposed. We also explored the potential of the newly developed compound 25 in the PDTC model to expand the original indications from ATC. In addition, an X-ray crystallographic study of the ligand and ERRgamma co-complex showed that 25 completely binds to the target protein (PDB 6KNR). Its medicinal chemistry, including a distinctive structural study to in vivo results, denotes that 25 may be directed towards the development of a pivotal treatment for ERRgamma-related cancers. | ||
| + | |||
| + | An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer.,Kim J, Hwang H, Yoon H, Lee JE, Oh JM, An H, Ji HD, Lee S, Cha E, Ma MJ, Kim DS, Lee SJ, Kadayat TM, Song J, Lee SW, Jeon JH, Park KG, Lee IK, Jeon YH, Chin J, Cho SJ Eur J Med Chem. 2020 Jul 14;205:112501. doi: 10.1016/j.ejmech.2020.112501. PMID:32758860<ref>PMID:32758860</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6knr" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Chin J]] | + | [[Category: Chin, J]] |
| - | [[Category: Cho | + | [[Category: Cho, S J]] |
| - | [[Category: Kim J]] | + | [[Category: Kim, J]] |
| - | [[Category: Song J]] | + | [[Category: Song, J]] |
| - | [[Category: Yoon H]] | + | [[Category: Yoon, H]] |
| + | [[Category: Estrogen-related receptor gamma]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 06:30, 19 August 2020
Crystal structure of Estrogen-related receptor gamma ligand-binding domain with DN200699
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