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6yg7

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==Crystal structure of MKK7 (MAP2K7) covalently bound with type-II inhibitor SB1-G-23==
==Crystal structure of MKK7 (MAP2K7) covalently bound with type-II inhibitor SB1-G-23==
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<StructureSection load='6yg7' size='340' side='right'caption='[[6yg7]]' scene=''>
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<StructureSection load='6yg7' size='340' side='right'caption='[[6yg7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YG7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YG7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6yg7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YG7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YG7 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yg7 OCA], [http://pdbe.org/6yg7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yg7 RCSB], [http://www.ebi.ac.uk/pdbsum/6yg7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yg7 ProSAT]</span></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=OQ2:~{N}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{R})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamide'>OQ2</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAP2K7, JNKK2, MEK7, MKK7, PRKMK7, SKK4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase Mitogen-activated protein kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.2 2.7.12.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yg7 OCA], [http://pdbe.org/6yg7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yg7 RCSB], [http://www.ebi.ac.uk/pdbsum/6yg7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yg7 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MP2K7_HUMAN MP2K7_HUMAN]] Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.<ref>PMID:9372971</ref> <ref>PMID:9312068</ref> <ref>PMID:9535930</ref> [:]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chaikuad A]]
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[[Category: Mitogen-activated protein kinase kinase]]
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[[Category: Gray NS]]
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[[Category: Chaikuad, A]]
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[[Category: Knapp S]]
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[[Category: Gray, N S]]
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[[Category: Liang Y]]
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[[Category: Knapp, S]]
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[[Category: Tan L]]
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[[Category: Liang, Y]]
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[[Category: Wang J]]
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[[Category: Structural genomic]]
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[[Category: Tan, L]]
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[[Category: Wang, J]]
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[[Category: Jnk signaling]]
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[[Category: Kinase]]
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[[Category: Kinase inhibitor]]
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[[Category: Map2k]]
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[[Category: Map2k7]]
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[[Category: Mek]]
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[[Category: Mek7]]
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[[Category: Mkk7]]
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[[Category: Sgc]]
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[[Category: Transferase]]

Revision as of 06:42, 19 August 2020

Crystal structure of MKK7 (MAP2K7) covalently bound with type-II inhibitor SB1-G-23

PDB ID 6yg7

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