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5mat
From Proteopedia
(Difference between revisions)
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==Structure of human Sirtuin 2 in complex with a selective thienopyrimidinone based inhibitor== | ==Structure of human Sirtuin 2 in complex with a selective thienopyrimidinone based inhibitor== | ||
| - | <StructureSection load='5mat' size='340' side='right' caption='[[5mat]], [[Resolution|resolution]] 2.07Å' scene=''> | + | <StructureSection load='5mat' size='340' side='right'caption='[[5mat]], [[Resolution|resolution]] 2.07Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5mat]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MAT OCA]. For a <b>guided tour on the structure components</b> use [http:// | + | <table><tr><td colspan='2'>[[5mat]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MAT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5MAT FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7KJ:(7~{R})-7-[(3,5-DIMETHYL-1,2-OXAZOL-4-YL)METHYLAMINO]-3-[(4-METHOXYNAPHTHALEN-1-YL)METHYL]-5,6,7,8-TETRAHYDRO-[1]BENZOTHIOLO[2,3-D]PYRIMIDIN-4-ONE'>7KJ</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7KJ:(7~{R})-7-[(3,5-DIMETHYL-1,2-OXAZOL-4-YL)METHYLAMINO]-3-[(4-METHOXYNAPHTHALEN-1-YL)METHYL]-5,6,7,8-TETRAHYDRO-[1]BENZOTHIOLO[2,3-D]PYRIMIDIN-4-ONE'>7KJ</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http:// | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SIRT2, SIR2L, SIR2L2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5mat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mat OCA], [http://pdbe.org/5mat PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mat RCSB], [http://www.ebi.ac.uk/pdbsum/5mat PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mat ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5mat" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5mat" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Moniot, S]] | [[Category: Moniot, S]] | ||
[[Category: Steegborn, C]] | [[Category: Steegborn, C]] | ||
Revision as of 07:14, 19 August 2020
Structure of human Sirtuin 2 in complex with a selective thienopyrimidinone based inhibitor
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