Histone methyltransferase 3D structures

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Line 47: Line 47:
**[[4mi5]] – hKHMT Ezh2 SET domain<br />
**[[4mi5]] – hKHMT Ezh2 SET domain<br />
**[[6by9]] - hKHMT EHMT1 residues 672-999<br />
**[[6by9]] - hKHMT EHMT1 residues 672-999<br />
 +
**[[6mm1]] - hKHMT EHMT2 Cys-rich domain residues 419-552<br />
**[[5v2n]] - hKHMT KMT5A residues 231-393<br />
**[[5v2n]] - hKHMT KMT5A residues 231-393<br />
**[[2j8a]] – KHMT SET1 RRM domain – yeast<br />
**[[2j8a]] – KHMT SET1 RRM domain – yeast<br />
Line 76: Line 77:
**[[3qox]], [[3sx0]] – hKHMT + SAH <br />
**[[3qox]], [[3sx0]] – hKHMT + SAH <br />
**[[2w5y]] – hKHMT Hrx methyltransferase domain + SAH <br />
**[[2w5y]] – hKHMT Hrx methyltransferase domain + SAH <br />
-
**[[3rib]] – hKHMT Smyd2 + SAH<br />
+
**[[3rib]], [[6n3g]] – hKHMT Smyd2 + SAH<br />
**[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br />
**[[3s7j]], [[3tg4]] - hKHMT Smyd2 + SAM<br />
**[[1mt6]] - hKHMT SET7/9 residues 58-337 + SAH<br />
**[[1mt6]] - hKHMT SET7/9 residues 58-337 + SAH<br />
Line 98: Line 99:
**[[5vse]], [[5vsc]], [[5vpi]] - hKHMT EHMT2 SET domain + inhibitor<br />
**[[5vse]], [[5vsc]], [[5vpi]] - hKHMT EHMT2 SET domain + inhibitor<br />
**[[6nm4]] - hKHMT Prdm9 zinc finger domain + inhibitor<br />
**[[6nm4]] - hKHMT Prdm9 zinc finger domain + inhibitor<br />
 +
**[[6ue6]], [[6xcg]] - hKHMT Nsd2 PWWP1 domain residues 211-350 + inhibitor<br />
**[[6g2o]], [[6g2f]], [[6g2e]], [[6g2c]], [[6g2b]], [[6g29]], [[6g27]], [[6g25]], [[6g24]] - hKHMT Nsd3 residues 247-398 + inhibitor<br />
**[[6g2o]], [[6g2f]], [[6g2e]], [[6g2c]], [[6g2b]], [[6g29]], [[6g27]], [[6g25]], [[6g24]] - hKHMT Nsd3 residues 247-398 + inhibitor<br />
 +
**[[6u9k]], [[6u9m]], [[6u9n]], [[6u9r]] - hKHMT MLL1 SET 167-333 (mutant) + inhibitor<br />
*Histone-lysine N-methyltransferase binary complexes with polypeptide
*Histone-lysine N-methyltransferase binary complexes with polypeptide
Line 124: Line 127:
**[[4x8p]], [[4x8n]] – hKHMT Ash2L Spry domain + RBBP5 <br />
**[[4x8p]], [[4x8n]] – hKHMT Ash2L Spry domain + RBBP5 <br />
**[[6e2h]] – hKHMT SET/Ash2 + DPY-30L <br />
**[[6e2h]] – hKHMT SET/Ash2 + DPY-30L <br />
 +
**[[6u4y]] - hKHMT Ezh2 + polycomb protein EED<br />
 +
**[[6jn2]] – hKHMT4 coiled-coil domain 470-550 + AF-10<br />
*Histone-lysine N-methyltransferase ternary complex containing polypeptide
*Histone-lysine N-methyltransferase ternary complex containing polypeptide
**[[2w5z]] – hKHMT Hrx methyltransferase domain + SAH + histone peptide<br />
**[[2w5z]] – hKHMT Hrx methyltransferase domain + SAH + histone peptide<br />
-
**[[5v22]], [[5v21]], [[5jlb]], [[5jjy]] - hKHMT SETD2 SET domain + SAH + H3 peptide<br />
+
**[[5v22]], [[5v21]], [[5jlb]], [[5jjy]] - hKHMT SETD2 catalytic domain 1434-1711 + SAH + H3 peptide<br />
 +
**[[6vdb]] - hKHMT SETD2 catalytic domain + SAH + peptide<br />
 +
**[[6jat]], [[6ox0]], [[6ox1]], [[6ox2]], [[6ox3]], [[6ox4]], [[6ox5]] - hKHMT SETD3 + sinefungin + actin peptide<br />
 +
**[[6v63]], [[6wk1]], [[6wk2]] - hKHMT SETD3 + SAH + actin peptide<br />
 +
**[[6v62]] - hKHMT SETD3 (mutant) + SAH + actin peptide<br />
**[[1o9s]] - hKHMT SET7/9 SET domain + SAH + H3 peptide<br />
**[[1o9s]] - hKHMT SET7/9 SET domain + SAH + H3 peptide<br />
**[[2bqz]] - hKHMT SET7 SET domain + SAH + H4 peptide<br />
**[[2bqz]] - hKHMT SET7 SET domain + SAH + H4 peptide<br />
Line 149: Line 158:
**[[4o6f]] – hKHMT Smyd2 (mutant) + SAH + estrogen receptor peptide<br />
**[[4o6f]] – hKHMT Smyd2 (mutant) + SAH + estrogen receptor peptide<br />
**[[5v3h]] – hKHMT Smyd2 (mutant) + SAM + inhibitor<br />
**[[5v3h]] – hKHMT Smyd2 (mutant) + SAM + inhibitor<br />
-
**[[5v37]] – hKHMT Smyd3 + SAM + inhibitor<br />
+
**[[5v37]], [[6p6k]], [[6p7z]], [[6paf]] – hKHMT Smyd3 + SAM + inhibitor<br />
 +
**[[6o9o]], [[6p6g]] – hKHMT Smyd3 + SAH + inhibitor<br />
**[[5hq8]] – hKHMT Smyd3 + SAH + MEKK2 peptide<br />
**[[5hq8]] – hKHMT Smyd3 + SAH + MEKK2 peptide<br />
**[[6ine]], [[6ago]] – hKHMT Ash1L + MRG15 + SAM <br />
**[[6ine]], [[6ago]] – hKHMT Ash1L + MRG15 + SAM <br />
Line 155: Line 165:
**[[4c1q]] - hKHMT SET domain + SAH + H3 peptide <br />
**[[4c1q]] - hKHMT SET domain + SAH + H3 peptide <br />
**[[4i51]] - hKHMT (mutant) + SAH + H3 peptide <br />
**[[4i51]] - hKHMT (mutant) + SAH + H3 peptide <br />
 +
**[[7bre]] – hKHMT Mll1 + RBBP5 + Ash2L<br />
**[[5f6l]] – hKHMT Mll1 (mutant) + RBBP5 + Ash2L<br />
**[[5f6l]] – hKHMT Mll1 (mutant) + RBBP5 + Ash2L<br />
**[[5f6k]] – hKHMT Mll3 + RBBP5 + Ash2L + peptide<br />
**[[5f6k]] – hKHMT Mll3 + RBBP5 + Ash2L + peptide<br />
Line 171: Line 182:
**[[5ttf]] - hKHMT EHMT2 catalytic domain + SAM + inhibitor<br />
**[[5ttf]] - hKHMT EHMT2 catalytic domain + SAM + inhibitor<br />
**[[3s7b]], [[5kjn]], [[5kjm]], [[5kjl]], [[5kjk]], [[5arg]], [[5arf]], [[4ynd]] - hKHMT Smyd2 + SAM + inhibitor<br />
**[[3s7b]], [[5kjn]], [[5kjm]], [[5kjl]], [[5kjk]], [[5arg]], [[5arf]], [[4ynd]] - hKHMT Smyd2 + SAM + inhibitor<br />
-
**[[5ccm]], [[5ccl]], [[5yjo]], [[5xxj]], [[5xxg]], [[5xxd]] – hKHMT Smyd3 + SAM + inhibitor<br />
+
**[[5ccm]], [[5ccl]], [[5yjo]], [[5xxj]], [[5xxg]], [[5xxd]], [[6ijl]] – hKHMT Smyd3 + SAM + inhibitor<br />
**[[1zkk]] - hKHMT + SAH + H4 peptide <br />
**[[1zkk]] - hKHMT + SAH + H4 peptide <br />
 +
**[[6in3]] – hKHMT4 + SAH + H4 peptide <br />
**[[4qen]], [[4qeo]], [[4qep]] – AtKHMT Suvh4 + DNA + SAH<br />
**[[4qen]], [[4qeo]], [[4qep]] – AtKHMT Suvh4 + DNA + SAH<br />
Line 183: Line 195:
**[[5ls6]], [[5hyn]] - hKHMT Ezh2 + polycomb protein + Jarid2 + inhibitor<br />
**[[5ls6]], [[5hyn]] - hKHMT Ezh2 + polycomb protein + Jarid2 + inhibitor<br />
**[[6c24]], [[6c23]] - hKHMT Ezh2 + polycomb repressor complex 2 – Cryo EM<br />
**[[6c24]], [[6c23]] - hKHMT Ezh2 + polycomb repressor complex 2 – Cryo EM<br />
 +
**[[6pwv]] - hKHMT 2A + MLL1 complex – Cryo EM<br />
 +
**[[6pww]] - hKHMT 2A + MLL1 complex + RBPP5 + WDR5 – Cryo EM<br />
 +
**[[6kiu]], [[6kiv]] - hKHMT 2A + MLL1-UBNCP complex – Cryo EM<br />
 +
**[[6kiw]] - hKHMT 2A + MLL3-UBNCP complex – Cryo EM<br />
 +
**[[6kix]], [[6kiz]] - hKHMT 2A + MLL1-NCP complex – Cryo EM<br />
 +
**[[6nzo]], [[6px3]], [[6ugm]], [[6uh5]] - fKHMT + nucleosome – frog – Cryo EM<br />
 +
**[[6uh5]] - fKHMT + nucleosome + ubiquitin – Cryo EM<br />
*Histone-arginine N-methyltransferase (Carm1)
*Histone-arginine N-methyltransferase (Carm1)
Line 197: Line 216:
**[[5u4x]] – hPRMT1 catalytic domain + SAH<br />
**[[5u4x]] – hPRMT1 catalytic domain + SAH<br />
**[[6nt2]] – hPRMT1 residues 1-371 + inhibitor<br />
**[[6nt2]] – hPRMT1 residues 1-371 + inhibitor<br />
-
**[[5dxj]] – hPRMT4 catalytic domain + sinefungin <br />
+
**[[5dxj]] – hPRMT4 catalytic domain 145-489 + sinefungin <br />
**[[4ikp]], [[6d2l]], [[6dvr]] – hPRMT4 catalytic domain + purine derivative<br />
**[[4ikp]], [[6d2l]], [[6dvr]] – hPRMT4 catalytic domain + purine derivative<br />
 +
**[[6izq]], [[6s70]], [[6s71]], [[6s74]], [[6s77]], [[6s79]], [[6s7a]], [[6s7b]], [[6s7c]], [[6te6]], [[6tel]], [[6ten]] – hPRMT4 catalytic domain + inhibitor<br />
**[[5egs]], [[5wcf]], [[5lv5]], [[5lv4]], [[5lv3]], [[5lv2]] – hPRMT6 + inhibitor<br />
**[[5egs]], [[5wcf]], [[5lv5]], [[5lv4]], [[5lv3]], [[5lv2]] – hPRMT6 + inhibitor<br />
**[[5ih3]] – mPRMT4 + SAH<br />
**[[5ih3]] – mPRMT4 + SAH<br />
Line 215: Line 235:
**[[2y1w]], [[2y1x]] – hPRMT4 catalytic domain + sinefungin + indole inhibitor<br />
**[[2y1w]], [[2y1x]] – hPRMT4 catalytic domain + sinefungin + indole inhibitor<br />
**[[6arv]], [[6arj]] – hPRMT4 catalytic domain + SAH + inhibitor<br />
**[[6arv]], [[6arj]] – hPRMT4 catalytic domain + SAH + inhibitor<br />
 +
**[[6rll]], [[6rlq]], [[6uxx]], [[6uxy]] – hPRMT5 + MEP50 + inhibitor<br />
 +
**[[6w6d]] – hPRMT6 1-375 + SAH + inhibitor<br />
**[[5lgs]], [[5lgr]], [[5lgq]], [[5lgp]] – mPRMT 4 + poly(A)-binding protein peptide + inhibitor<br />
**[[5lgs]], [[5lgr]], [[5lgq]], [[5lgp]] – mPRMT 4 + poly(A)-binding protein peptide + inhibitor<br />
**[[4gqb]], [[5fa5]] – hPRMT5 + methylosome protein 50 + H4 peptide<br />
**[[4gqb]], [[5fa5]] – hPRMT5 + methylosome protein 50 + H4 peptide<br />

Revision as of 08:43, 20 August 2020

3D Structures of histone methyltransferase

Updated on 20-August-2020

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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