Inorganic pyrophosphatase
From Proteopedia
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<StructureSection load='2bqy' size='350' side='right' scene='48/488499/Cv/1' caption='Inorganic pyrophosphatase complex with pyrophosphate, [[2bqy]]'> | <StructureSection load='2bqy' size='350' side='right' scene='48/488499/Cv/1' caption='Inorganic pyrophosphatase complex with pyrophosphate, [[2bqy]]'> | ||
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== Function == | == Function == | ||
'''Inorganic pyrophosphatase''' (PPase) catalyzes the breakdown of pyrophosphate (PPi) to two molecules of phosphate (PO4). The reaction releases energy and is irreversible hence it is coupled to biochemical reactions which need to be driven to completion. PPase plays a role in lipid metabolism, calcium absorption, bone formation and DNA synthesis. PPase requires a divalent metal ion like Mg+2 for higher activity. PPi is formed in many biosynthetic reactions which require ATP<ref>PMID:5342521</ref>. | '''Inorganic pyrophosphatase''' (PPase) catalyzes the breakdown of pyrophosphate (PPi) to two molecules of phosphate (PO4). The reaction releases energy and is irreversible hence it is coupled to biochemical reactions which need to be driven to completion. PPase plays a role in lipid metabolism, calcium absorption, bone formation and DNA synthesis. PPase requires a divalent metal ion like Mg+2 for higher activity. PPi is formed in many biosynthetic reactions which require ATP<ref>PMID:5342521</ref>. | ||
Revision as of 08:11, 24 August 2020
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References
- ↑ Harold FM. Inorganic polyphosphates in biology: structure, metabolism, and function. Bacteriol Rev. 1966 Dec;30(4):772-94. PMID:5342521
- ↑ Chao TC, Huang H, Tsai JY, Huang CY, Sun YJ. Kinetic and structural properties of inorganic pyrophosphatase from the pathogenic bacterium Helicobacter pylori. Proteins. 2006 Nov 15;65(3):670-80. PMID:16988955 doi:10.1002/prot.21093
