Ire1

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Revision as of 10:38, 25 August 2020

Structure of yeast Ire1 cytoplasmic domain dimer complex with quercetin, ADP, Ca+2 and Sr+2 ions (PDB entry 3lj0)

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 <StructureSection load='3lj0' size='400' side='right' caption='Structure of yeast Ire1 cytoplasmic domain dimer complex with quercetin, ADP, Ca+2 and Sr+2 ions (PDB entry [[3lj0]])' scene='51/516469/Cv/1'>
 == Function ==
-'''Ire1''' is a serine/threonine protein kinase/endoribonuclease.  It is important in altering gene expression as a response to endoplasmic reticulum-based stress signals<ref>PMID:11034898</ref>.  The endoribonuclase domain of Ire1 is a transcriptional activator which triggers growth arrest and apoptosis.  The kinase domain of Ire1 is required for activation of the endoribonuclase domain.  Ire1 senses unfolded proteins causing its auto-activation.
+'''Ire1''' or '''serine/threonine protein kinase/endoribonuclease Ire1'''.  It is important in altering gene expression as a response to endoplasmic reticulum-based stress signals<ref>PMID:11034898</ref>.  The endoribonuclase domain of Ire1 is a transcriptional activator which triggers growth arrest and apoptosis.  The kinase domain of Ire1 is required for activation of the endoribonuclase domain.  Ire1 senses unfolded proteins causing its auto-activation.
 == Structural highlights ==