1cg8

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[[Image:1cg8.jpg|left|200px]]
[[Image:1cg8.jpg|left|200px]]
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{{Structure
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|PDB= 1cg8 |SIZE=350|CAPTION= <scene name='initialview01'>1cg8</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1cg8", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=HMA:O2+Binding+Site'>HMA</scene> and <scene name='pdbsite=HMB:O2+Binding+Site'>HMB</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1cg8| PDB=1cg8 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cg8 OCA], [http://www.ebi.ac.uk/pdbsum/1cg8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cg8 RCSB]</span>
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}}
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'''CO Form Hemoglobin from Dasyatis Akajei'''
'''CO Form Hemoglobin from Dasyatis Akajei'''
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[[Category: Chong, K T.]]
[[Category: Chong, K T.]]
[[Category: Morimoto, H.]]
[[Category: Morimoto, H.]]
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[[Category: oxygen transport]]
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[[Category: Oxygen transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:42:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:21:08 2008''
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Revision as of 09:42, 2 May 2008

Image:1cg8.jpg

Template:STRUCTURE 1cg8

CO Form Hemoglobin from Dasyatis Akajei


Overview

The three-dimensional structures of the deoxy- and carbonmonoxyhaemoglobin (Hb) from Dasyatis akajei, a stingray, have been determined at 1.6 and 1.9 A resolution, respectively. This is one of the most distantly related vertebrate Hbs to human HbA. Both structures resemble the respective forms of HbA, indicating that the alpha2beta2-type tetramer and the mode of the quaternary structure change are common to Hbs of jawed vertebrates. Larger deviations between D. akajei Hb and human HbA are observed in various parts of the molecule, even in the E and F helices. Significant mutations and/or conformational changes are also observed around the haems, in the C-terminal region of the beta subunit, in the alpha1beta2 interface and in the organic phosphate-binding site of HbA. Despite these structural differences, the oxygen affinity, haem-haem interaction, Bohr effect and organic phosphate effect of D. akajei Hb are all only moderately reduced. Compared with human HbA, the overall r.m.s. deviation of main-chain atoms in the helical regions of bony fish Hbs is smaller than that of D. akajei Hb.

About this Structure

1CG8 is a Protein complex structure of sequences from Dasyatis akajei. Full crystallographic information is available from OCA.

Reference

Structures of the deoxy and CO forms of haemoglobin from Dasyatis akajei, a cartilaginous fish., Chong KT, Miyazaki G, Morimoto H, Oda Y, Park SY, Acta Crystallogr D Biol Crystallogr. 1999 Jul;55(Pt 7):1291-300. PMID:10393295 Page seeded by OCA on Fri May 2 12:42:17 2008

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