5nu8

From Proteopedia

(Difference between revisions)

Revision as of 12:12, 26 August 2020

Structure of human urine RBP4 saturated with palmitate

Structural highlights

5nu8 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	5nu2
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[RET4_HUMAN] Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [MIM:180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.

Function

[RET4_HUMAN] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.

Publication Abstract from PubMed

RBP4 (plasma retinol-binding protein) is the 21kDa transporter of all-trans retinol that circulates in plasma as a moderately tight 1:1 molar complex of the vitamin with the protein. RBP4 is primarily synthesized in the liver but is also produced by adipose tissue and circulates bound to a larger protein, transthyretin, TTR, that serves to increase its molecular mass and thus avoid its elimination by glomerular filtration. This paper reports the high resolution three-dimensional structures of human RBP4 naturally lacking bound retinol purified from plasma, urine and amniotic fluid. In all these crystals we found a fatty acid molecule bound in the hydrophobic ligand-binding site, a result confirmed by mass spectrometry measurements. In addition we also report the 1.5A resolution structures of human holo-RBP4 and of the protein saturated with palmitic and lauric acid and discuss the interaction of the fatty acids and retinol with the protein.

Human plasma retinol-binding protein (RBP4) is also a fatty acid-binding protein.,Perduca M, Nicolis S, Mannucci B, Galliano M, Monaco HL Biochim Biophys Acta. 2018 Apr;1863(4):458-466. doi:, 10.1016/j.bbalip.2018.01.010. PMID:29414511^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Perduca M, Nicolis S, Mannucci B, Galliano M, Monaco HL. Human plasma retinol-binding protein (RBP4) is also a fatty acid-binding protein. Biochim Biophys Acta. 2018 Apr;1863(4):458-466. doi:, 10.1016/j.bbalip.2018.01.010. PMID:29414511 doi:http://dx.doi.org/10.1016/j.bbalip.2018.01.010

1 Structural highlights
2 Disease
3 Function
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5nu8"

@@ Line 1: / Line 1: @@
 ==Structure of human urine RBP4 saturated with palmitate==
-<StructureSection load='5nu8' size='340' side='right' caption='[[5nu8]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
+<StructureSection load='5nu8' size='340' side='right'caption='[[5nu8]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5nu8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NU8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NU8 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5nu8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NU8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5NU8 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5nu2|5nu2]]</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nu8 OCA], [http://pdbe.org/5nu8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nu8 RCSB], [http://www.ebi.ac.uk/pdbsum/5nu8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nu8 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5nu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nu8 OCA], [http://pdbe.org/5nu8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nu8 RCSB], [http://www.ebi.ac.uk/pdbsum/5nu8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nu8 ProSAT]</span></td></tr>
 </table>
 == Disease ==
@@ Line 21: / Line 21: @@
 </div>
 <div class="pdbe-citations 5nu8" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Retinol-binding protein 3D structures|Retinol-binding protein 3D structures]]
 == References ==
 <references/>
@@ Line 26: / Line 29: @@
 </StructureSection>
 [[Category: Homo sapiens]]
+[[Category: Large Structures]]
 [[Category: Galliano, M]]
 [[Category: Monaco, H L]]

5nu8

From Proteopedia

Revision as of 12:12, 26 August 2020

Structure of human urine RBP4 saturated with palmitate

Structural highlights

Disease

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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