1cit

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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cit OCA], [http://www.ebi.ac.uk/pdbsum/1cit PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cit RCSB]</span>
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'''DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B'''
'''DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B'''
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[[Category: Meinke, G.]]
[[Category: Meinke, G.]]
[[Category: Sigler, P B.]]
[[Category: Sigler, P B.]]
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[[Category: early immediate response gene product]]
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[[Category: Early immediate response gene product]]
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[[Category: minor groove interaction]]
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[[Category: Minor groove interaction]]
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[[Category: monomeric protein-dna complex]]
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[[Category: Monomeric protein-dna complex]]
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[[Category: orphan nuclear receptor]]
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[[Category: Orphan nuclear receptor]]
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[[Category: protein/dna]]
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[[Category: Protein/dna]]
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[[Category: transcription factor]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:46:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:22:30 2008''
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Revision as of 09:46, 2 May 2008

Image:1cit.gif

Template:STRUCTURE 1cit

DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B


Overview

The 2.7 A X-ray crystal structure of the DNA-binding domain (DBD) of the orphan nuclear receptor, nerve growth factor-induced-B (NGFI-B), complexed to its high-affinity DNA target, represents the first structure analysis of a nuclear receptor DBD bound as a monomer to DNA. The structure of the core DBD and its interactions with the major groove of the DNA are similar to previously crystallographically solved DBD-DNA complexes in this superfamily; however, residues C-terminal to this core form a separate and unique substructure that interacts extensively and in a sequence-specific way with the minor groove of its DNA target, in particular with the characteristic 3 A-T base-pair identity element that extends 5' to the usual nuclear receptor half-site (AGGTCA).

About this Structure

1CIT is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

DNA-binding mechanism of the monomeric orphan nuclear receptor NGFI-B., Meinke G, Sigler PB, Nat Struct Biol. 1999 May;6(5):471-7. PMID:10331876 Page seeded by OCA on Fri May 2 12:46:36 2008

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