5ow8

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==Indole-2 carboxamides as selective secreted phospholipase A2 type X (sPLA2-X) inhibitors==
==Indole-2 carboxamides as selective secreted phospholipase A2 type X (sPLA2-X) inhibitors==
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<StructureSection load='5ow8' size='340' side='right' caption='[[5ow8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='5ow8' size='340' side='right'caption='[[5ow8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ow8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OW8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OW8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ow8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OW8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5OW8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AYN:1-[3-(trifluoromethyl)phenyl]indole-2-carboxamide'>AYN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AYN:1-[3-(trifluoromethyl)phenyl]indole-2-carboxamide'>AYN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ow8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ow8 OCA], [http://pdbe.org/5ow8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ow8 RCSB], [http://www.ebi.ac.uk/pdbsum/5ow8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ow8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ow8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ow8 OCA], [http://pdbe.org/5ow8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ow8 RCSB], [http://www.ebi.ac.uk/pdbsum/5ow8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ow8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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</div>
</div>
<div class="pdbe-citations 5ow8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ow8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Bodin, C]]
[[Category: Bodin, C]]
[[Category: Knerr, L]]
[[Category: Knerr, L]]

Revision as of 07:32, 2 September 2020

Indole-2 carboxamides as selective secreted phospholipase A2 type X (sPLA2-X) inhibitors

PDB ID 5ow8

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