Mitogen-activated protein kinase kinase kinase

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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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* MAP3K1
+
* MAP3K1; Domains – kinase 10-307; SH3-binding 465-480; TOG 648-867
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**[[1uti]] - MAP3K1+GRB2-related adaptor protein 2 - mouse
+
**[[6nfy]], [[6nfz]] - hMAP3K1 kinase domain + cancer drug - human<br />
 +
**[[6ng0]] - hMAP3K1 kinase domain (mutant) + cancer drug <br />
 +
**[[6nyb]] - hMAP3K1 kinase domain (mutant) + B-raf + 14-3-3 protein ζ – Cryo EM<br />
 +
**[[6whb]] - hMAP3K1 TOG domain + cancer drug <br />
 +
 
 +
**[[1uti]] - MAP3K1 SH3-binding domain +GRB2-related adaptor protein 2 - mouse
*MAP3K2
*MAP3K2
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**[[2cu1]] - hMAP3K2 PB1 domain (mutant) - human - NMR<br />
+
**[[2cu1]] - hMAP3K2 PB1 domain (mutant) - NMR<br />
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**[[2o2v]], [[5uoj]] – hMAP3K2+hMAP3K5 - human<br />
+
**[[2o2v]], [[5uoj]] – hMAP3K2+hMAP3K<br />
**[[2npt]] - hMAP3K2 PHOX domain + hMAP2K5 PHOX domain
**[[2npt]] - hMAP3K2 PHOX domain + hMAP2K5 PHOX domain
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**[[2clq]] – hMAP3K5<br />
**[[2clq]] – hMAP3K5<br />
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**[[4bf2]], [[4bhn]], [[4bib]], [[4bic]], [[4bid]], [[4bie]] - hMAP3K5 (mutant) + inhibitor<br />
+
**[[6oyt]], [[6vre]], [[6xih]] - hMAP3K5 + inhibitor<br />
 +
**[[4bf2]], [[4bhn]], [[4bib]], [[4bic]], [[4bid]], [[4bie]], [[6e2m]], [[6e2n]], [[6e2o]], [[6oyw]] - hMAP3K5 (mutant) + inhibitor<br />
*MAP3K7 (TAK1)
*MAP3K7 (TAK1)
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**[[2rf0]] - hMAP3K10 SH3 domain - NMR
**[[2rf0]] - hMAP3K10 SH3 domain - NMR
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*MAP3K14
+
*MAP3K14 kinase domain 343-686
**[[4dn5]] - hMAP3K14 (mutant) + ATP-γ-S<br />
**[[4dn5]] - hMAP3K14 (mutant) + ATP-γ-S<br />
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**[[4idt]], [[4idv]] - hMAP3K14 + inhibitor<br />
+
**[[4idt]], [[4idv]], [[6wpp]] - hMAP3K14 + inhibitor<br />
 +
**[[6g4y]], [[6g4z]], [[6myn]] - mMAP3K14 + inhibitor<br />
 +
 
 +
*MAP3K15
 +
 
 +
**[[6v0m]] - hMAP3K15 residues 1241-1308<br />
 +
 
 +
*MAP3K MLT
 +
 
 +
**[[6jut]], [[6juu]] - hMAP3K + inhibitor<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:30, 8 September 2020

Mitogen-activated protein kinase kinase kinase 3 (green) complex with MAP2K5 PHOX domain (grey) (PDB code 2o2v).

Drag the structure with the mouse to rotate

3D Structures of Mitogen-activated protein kinase kinase kinase

Updated on 08-September-2020

References

  1. ↑ Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative. J Biol Chem. 1997 Jan 31;272(5):2668-74. PMID:9006902
  2. ↑ Santen RJ, Song RX, McPherson R, Kumar R, Adam L, Jeng MH, Yue W. The role of mitogen-activated protein (MAP) kinase in breast cancer. J Steroid Biochem Mol Biol. 2002 Feb;80(2):239-56. PMID:11897507

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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