1cjy

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[[Image:1cjy.gif|left|200px]]
[[Image:1cjy.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1cjy |SIZE=350|CAPTION= <scene name='initialview01'>1cjy</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1cjy", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1cjy| PDB=1cjy | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cjy OCA], [http://www.ebi.ac.uk/pdbsum/1cjy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cjy RCSB]</span>
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}}
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'''HUMAN CYTOSOLIC PHOSPHOLIPASE A2'''
'''HUMAN CYTOSOLIC PHOSPHOLIPASE A2'''
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Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism., Dessen A, Tang J, Schmidt H, Stahl M, Clark JD, Seehra J, Somers WS, Cell. 1999 Apr 30;97(3):349-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10319815 10319815]
Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism., Dessen A, Tang J, Schmidt H, Stahl M, Clark JD, Seehra J, Somers WS, Cell. 1999 Apr 30;97(3):349-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10319815 10319815]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phospholipase A(2)]]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Clark, J D.]]
[[Category: Clark, J D.]]
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[[Category: Stahl, M.]]
[[Category: Stahl, M.]]
[[Category: Tang, J.]]
[[Category: Tang, J.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: lipid-binding]]
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[[Category: Lipid-binding]]
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[[Category: phospholipase]]
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[[Category: Phospholipase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:48:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:23:12 2008''
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Revision as of 09:48, 2 May 2008

Image:1cjy.gif

Template:STRUCTURE 1cjy

HUMAN CYTOSOLIC PHOSPHOLIPASE A2


Overview

Cytosolic phospholipase A2 initiates the biosynthesis of prostaglandins, leukotrienes, and platelet-activating factor (PAF), mediators of the pathophysiology of asthma and arthritis. Here, we report the X-ray crystal structure of human cPLA2 at 2.5 A. cPLA2 consists of an N-terminal calcium-dependent lipid-binding/C2 domain and a catalytic unit whose topology is distinct from that of other lipases. An unusual Ser-Asp dyad located in a deep cleft at the center of a predominantly hydrophobic funnel selectively cleaves arachidonyl phospholipids. The structure reveals a flexible lid that must move to allow substrate access to the active site, thus explaining the interfacial activation of this important lipase.

About this Structure

1CJY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism., Dessen A, Tang J, Schmidt H, Stahl M, Clark JD, Seehra J, Somers WS, Cell. 1999 Apr 30;97(3):349-60. PMID:10319815 Page seeded by OCA on Fri May 2 12:48:56 2008

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