1ck7

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[[Image:1ck7.gif|left|200px]]
[[Image:1ck7.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ck7 |SIZE=350|CAPTION= <scene name='initialview01'>1ck7</scene>, resolution 2.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1ck7", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Gelatinase_A Gelatinase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.24 3.4.24.24] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1ck7| PDB=1ck7 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ck7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ck7 OCA], [http://www.ebi.ac.uk/pdbsum/1ck7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ck7 RCSB]</span>
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}}
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'''GELATINASE A (FULL-LENGTH)'''
'''GELATINASE A (FULL-LENGTH)'''
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[[Category: Tryggvason, K.]]
[[Category: Tryggvason, K.]]
[[Category: Tuuttila, A.]]
[[Category: Tuuttila, A.]]
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[[Category: full-length]]
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[[Category: Full-length]]
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[[Category: gelatinase some]]
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[[Category: Gelatinase some]]
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[[Category: hydrolase (metalloprotease)]]
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[[Category: Metalloproteinase]]
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[[Category: metalloproteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:49:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:23:11 2008''
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Revision as of 09:49, 2 May 2008

Image:1ck7.gif

Template:STRUCTURE 1ck7

GELATINASE A (FULL-LENGTH)


Overview

Matrix metalloproteinases (MMPs) catalyze extracellular matrix degradation. Control of their activity is a promising target for therapy of diseases characterized by abnormal connective tissue turnover. MMPs are expressed as latent proenzymes that are activated by proteolytic cleavage that triggers a conformational change in the propeptide (cysteine switch). The structure of proMMP-2 reveals how the propeptide shields the catalytic cleft and that the cysteine switch may operate through cleavage of loops essential for propeptide stability.

About this Structure

1CK7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed., Morgunova E, Tuuttila A, Bergmann U, Isupov M, Lindqvist Y, Schneider G, Tryggvason K, Science. 1999 Jun 4;284(5420):1667-70. PMID:10356396 Page seeded by OCA on Fri May 2 12:49:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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