This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ck7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1ck7.gif|left|200px]]
[[Image:1ck7.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1ck7 |SIZE=350|CAPTION= <scene name='initialview01'>1ck7</scene>, resolution 2.8&Aring;
+
The line below this paragraph, containing "STRUCTURE_1ck7", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Gelatinase_A Gelatinase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.24 3.4.24.24] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1ck7| PDB=1ck7 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ck7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ck7 OCA], [http://www.ebi.ac.uk/pdbsum/1ck7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ck7 RCSB]</span>
+
-
}}
+
'''GELATINASE A (FULL-LENGTH)'''
'''GELATINASE A (FULL-LENGTH)'''
Line 33: Line 30:
[[Category: Tryggvason, K.]]
[[Category: Tryggvason, K.]]
[[Category: Tuuttila, A.]]
[[Category: Tuuttila, A.]]
-
[[Category: full-length]]
+
[[Category: Full-length]]
-
[[Category: gelatinase some]]
+
[[Category: Gelatinase some]]
-
[[Category: hydrolase (metalloprotease)]]
+
[[Category: Metalloproteinase]]
-
[[Category: metalloproteinase]]
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:49:27 2008''
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:23:11 2008''
+

Revision as of 09:49, 2 May 2008

Image:1ck7.gif

Template:STRUCTURE 1ck7

GELATINASE A (FULL-LENGTH)


Overview

Matrix metalloproteinases (MMPs) catalyze extracellular matrix degradation. Control of their activity is a promising target for therapy of diseases characterized by abnormal connective tissue turnover. MMPs are expressed as latent proenzymes that are activated by proteolytic cleavage that triggers a conformational change in the propeptide (cysteine switch). The structure of proMMP-2 reveals how the propeptide shields the catalytic cleft and that the cysteine switch may operate through cleavage of loops essential for propeptide stability.

About this Structure

1CK7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed., Morgunova E, Tuuttila A, Bergmann U, Isupov M, Lindqvist Y, Schneider G, Tryggvason K, Science. 1999 Jun 4;284(5420):1667-70. PMID:10356396 Page seeded by OCA on Fri May 2 12:49:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ck7"
Personal tools