Nuclear receptor corepressor

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 19: Line 19:
*Nuclear receptor corepressor 1
*Nuclear receptor corepressor 1
-
**[[2eqr]] – hN-CoR1 SANT domain – human - NMR<br />
+
**[[2eqr]] – hN-CoR1 SANT1 domain 433-486 – human - NMR<br />
**[[3kmz]] – hN-CoR1 SMRT2 domain + retinoic acid receptor<br />
**[[3kmz]] – hN-CoR1 SMRT2 domain + retinoic acid receptor<br />
**[[3n00]] – hN-CoR1 SMRT2 domain + REV-ERBA-a<br />
**[[3n00]] – hN-CoR1 SMRT2 domain + REV-ERBA-a<br />
Line 25: Line 25:
**[[3h52]], [[4mdd]] – hN-CoR1 residues 2258-2276 + glucocorticoid receptor + antagonist<br />
**[[3h52]], [[4mdd]] – hN-CoR1 residues 2258-2276 + glucocorticoid receptor + antagonist<br />
**[[4wvd]] – hN-CoR1 residues 2258-2276 + bile acid receptor + antagonist<br />
**[[4wvd]] – hN-CoR1 residues 2258-2276 + bile acid receptor + antagonist<br />
-
**[[4y29]] – hN-CoR1 residues 1432-1441 + PPAR-g + celerythrine<br />
+
**[[4y29]] – hN-CoR1 residues 1432-1441 + PPAR-γ + celerythrine<br />
*Nuclear receptor corepressor 2
*Nuclear receptor corepressor 2
-
**[[2ltp]] – hN-CoR2 SANT2 domain - NMR<br />
+
**[[2ltp]] – hN-CoR2 SANT2 domain 615-685 - NMR<br />
-
**[[1xc5]] – hN-CoR2 SMRT domain - NMR<br />
+
**[[1xc5]] – hN-CoR2 SMRT domain 410-480 - NMR<br />
 +
**[[6oni]] – hNCOR2 residues 776-798 + PPAR-γ + inhibitor<br />
 +
**[[6pdz]] – hNCOR2 residues 2318-2339 + PPAR-γ + inhibitor<br />
**[[4a69]] – hN-CoR2 SMRT domain + histone deacetylase 3 + inositol tetraphosphate<br />
**[[4a69]] – hN-CoR2 SMRT domain + histone deacetylase 3 + inositol tetraphosphate<br />
-
**[[3r2a]] – hN-CoR2 SMRT2 domain + retinoic acid receptor + Rhein<br />
+
**[[3r2a]] – hN-CoR2 SMRT2 domain 2346-2361 + retinoic acid receptor + Rhein<br />
-
**[[1kkq]] – hN-CoR2 SMRT2 domain + PPAR-a<br />
+
**[[1kkq]] – hN-CoR2 SMRT2 domain + PPAR-α<br />
**[[5x8x]] – hN-CoR2 SMRT2 domain + protein<br />
**[[5x8x]] – hN-CoR2 SMRT2 domain + protein<br />
**[[4oar]] – hN-CoR2 SMRT2 domain + progesterone receptor<br />
**[[4oar]] – hN-CoR2 SMRT2 domain + progesterone receptor<br />
-
**[[2gpv]] – hN-CoR2 SMRT2 domain + estrogen-related receptor-g + tamoxifen<br />
+
**[[2gpv]] – hN-CoR2 SMRT2 domain + estrogen-related receptor-γ + tamoxifen<br />
-
**[[5x8q]] – hN-CoR2 SMRT2 domain + nuclear receptor ROR-g + rockogenin<br />
+
**[[5x8q]] – hN-CoR2 SMRT2 domain + nuclear receptor ROR-γ + rockogenin<br />
 +
**[[6a22]], [[6ivx]] – hNCOR2 SMRT2 domain + nuclear receptor ROR-γ + inhibitor<br />
**[[1r2b]] – hN-CoR2 SMRT residues 1414-1430 + BCL6<br />
**[[1r2b]] – hN-CoR2 SMRT residues 1414-1430 + BCL6<br />

Revision as of 08:29, 14 September 2020

Structure of human nuclear receptor corepressor 2 SMRT (magenta, cyan) complex with retinoic acid receptor LBD (grey, green, pink, yellow) and the antagonistic ligand Rhein (PDB entry 3r2a)

Drag the structure with the mouse to rotate

3D Structures of nuclear receptor corepressor

Updated on 14-September-2020

References

  1. ↑ Xu HE, Stanley TB, Montana VG, Lambert MH, Shearer BG, Cobb JE, McKee DD, Galardi CM, Plunket KD, Nolte RT, Parks DJ, Moore JT, Kliewer SA, Willson TM, Stimmel JB. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. Nature. 2002 Feb 14;415(6873):813-7. PMID:11845213 doi:10.1038/415813a
  2. ↑ Webb P, Anderson CM, Valentine C, Nguyen P, Marimuthu A, West BL, Baxter JD, Kushner PJ. The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/LXXII) that serve as receptor interaction domains (IDs). Mol Endocrinol. 2000 Dec;14(12):1976-85. doi: 10.1210/mend.14.12.0566. PMID:11117528 doi:http://dx.doi.org/10.1210/mend.14.12.0566
  3. ↑ Fozzatti L, Park JW, Zhao L, Willingham MC, Cheng SY. Oncogenic Actions of the Nuclear Receptor Corepressor (NCOR1) in a Mouse Model of Thyroid Cancer. PLoS One. 2013 Jun 26;8(6):e67954. doi: 10.1371/journal.pone.0067954. Print 2013. PMID:23840792 doi:http://dx.doi.org/10.1371/journal.pone.0067954
  4. ↑ Reilly SM, Bhargava P, Liu S, Gangl MR, Gorgun C, Nofsinger RR, Evans RM, Qi L, Hu FB, Lee CH. Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration. Cell Metab. 2010 Dec 1;12(6):643-53. doi: 10.1016/j.cmet.2010.11.007. PMID:21109196 doi:http://dx.doi.org/10.1016/j.cmet.2010.11.007
  5. ↑ Zhang H, Chen L, Chen J, Jiang H, Shen X. Structural basis for retinoic X receptor repression on the tetramer. J Biol Chem. 2011 May 24. PMID:21613212 doi:10.1074/jbc.M111.245498

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Nuclear_receptor_corepressor"
Personal tools