Sandbox GGC5

From Proteopedia

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==FABP3 with myristic acid==
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==Your Heading Here (maybe something like 'Structure')==
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<StructureSection load='78/781193/Overall/1'</scene>
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<StructureSection load='3VEV' size='340' side='right' caption='Caption for this structure' scene=''>
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Heart-type Fatty acid-binding proteins (H-FABP/FABP3) are cytoplasmic carrier protein that active fatty acid metabolism in the heart; found in cardiomyocytes.
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This is a default text for your page '''Sandbox GGC5'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
== Function ==
== Function ==
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Heart-type fatty acid binding protein (H-FABP) found in heart and skeletal muscle tissue. FABP3 involved in fatty acid metabolism by myristic acid.
 
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Myristic acid is long saturated fatty acid chain that found in plant and animal, especially in milk fat. It produced during human metabolism and binds with FAPB3.
 
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Hexaethylene glycol used in crystallized FABP3 with myristic acid.
 
== Disease ==
== Disease ==
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Pulmonary Embolism is lung disease that occurs when blood clots block the one of the pulmonary arteries. It blocks blood and oxygen flow and can causes pulmonary infarction when it gets severe. <br />
 
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Acute Myocardial Infarction is heart attack that due to cholesterol, saturated fat, and trans-fat build plaque and block the arteries which causes cardio tissue damage.
 
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== Structure ==
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== Relevance ==
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<scene name='78/781193/Overall/1'>4 amino acids</scene> Lysine (orange), arginine (turquoise), tyrosine (purple), and serine (yellow) <br />
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<scene name='78/781193/Myr_hydrogen_bonds/2'>Myristic acid</scene> Tyr128 formed hydrogen bond with O2 of MYR and epsilon nitrogen and one of NH2 of Arg128 formed hydrogen bond with hydroxyl MYR. <br />
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<scene name='78/781193/P6g_with_lys_and_ser/2'>Hexaethylene glycol</scene> Lys37 formed hydrogen bond with 4 oxygens (1,4,7, and 10) of P6G and ketone group of Ser34 formed hydrogen bond with hydroxyl group of P6G.
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</StructureSection>
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== Structural highlights ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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</StructureSection>
== References ==
== References ==
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<references/Matsuoka, Shigeru, et al. “Water-Mediated Recognition of Simple Alkyl Chains by Heart-Type Fatty-Acid-Binding Protein.” Angewandte Chemie International Edition, vol. 54, no. 5, 2014, pp. 1508–1511., doi:10.1002/anie.201409830.>
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<references/>
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<references/Myristic acid and Lauric acid. https://www.acs.org/content/acs/en/molecule-of-the-week/archive/m/myristic-acid.html (accessed Nov 6, 2019).>
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<references/National Center for Biotechnology Information. PubChem Database. Myristic acid, CID=11005, https://pubchem.ncbi.nlm.nih.gov/compound/Myristic-acid (accessed on Nov. 6, 2019)>
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<references/Mechanic, O. J. (2019, August 15). Acute Myocardial Infarction. Retrieved from
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https://www.ncbi.nlm.nih.gov/books/NBK459269/.>
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<references/Pulmonary embolism. (2018, March 7). Retrieved from https://www.mayoclinic.org/diseases
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conditions/pulmonary-embolism/symptoms-causes/syc-20354647.>
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Revision as of 10:00, 14 September 2020

Your Heading Here (maybe something like 'Structure')

Caption for this structure

Drag the structure with the mouse to rotate

References

  1. Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
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