Sandbox GGC12

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==TATA-Binding Protein (TBP)==
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==Your Heading Here (maybe something like 'Structure')==
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<StructureSection load='3VEV' size='340' side='right' caption='Caption for this structure' scene=''>
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<StructureSection load='1tgh' size='340' side='right' caption='Caption for this structure' scene='78/781196/Tata_binding_protein/1''>
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This is a default text for your page '''Sandbox GGC12'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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== Structure ==
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The structure of the <scene name='78/781196/Tata_binding_protein/4'>TATA-Binding Protein (TBP)</scene> has a pseudo-symmetry within its structure which contains two 88-amino acid repeats. The <scene name='78/781196/Tata-binding_protein/2'>secondary structures</scene> of this protein include both Alpha and Beta components on the distribution of the symmetry. This structure attaches to a DNA structure of deformity in the helix; the deformity is for the purpose of binding. The DNA structure's <scene name='78/781196/Inner_connections/1'>inner connections</scene> show the minor groove is wide open to have complete access for the TBP to bind within it (2). Some interactions are with the minor groove, and some interactions are with the sugar/ phosphate helix within the backbone.
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== Function ==
== Function ==
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The TATA-Binding protein, TBP, is a factor in the process of Transcription within Eukaryotes. This binding protein is a subunit in the family of TFIID. The function of the TBP is to bind to a DNA sequence which is the TATA box. The <scene name='78/781196/Tbp_plus_tata_box/6'>composition of the structure</scene> shows the protein (the TATA-Binding Protein) attaching to the DNA sequence (the TATA box). This allows RNA Polymerase II to bind to the promoter. This is the beginning of the process of Transcription (3).
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== Disease ==
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== Relevance ==
== Relevance ==
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The TATA-Binding Protein is relevant to everyday life because humans contain this specific protein as well with or without a promoter. This process is happening in multiple tissues and cells at a time (1). Although it may not have any diseases
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== Structural highlights ==
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connected with it, the protein is needed in everyday life.
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== Interesting Facts about the TBP ==
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-The first ever for the TBP was found in fruit flies, specifically Drosophila flies.
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-This is not the same idea in prokaryotes. Prokaryotes have a different concept because it is a Pribnow box instead of a TATA box (2).
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-Another name for the TATA box is the Goldberg-Hogness box (1).
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>
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1. Imbalzano, A., Kwon, H., Green, M. et al. Facilitated binding of TATA-binding protein to nucleosomal DNA. Nature 370, 481–485 (1994) doi:10.1038/370481a0
 
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2. Juo, Zong Sean, et al. “How Proteins Recognize the TATA Box.” Journal of Molecular Biology, vol. 261, no. 2, 1996, pp. 239–254., doi:10.1006/jmbi.1996.0456.
 
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3. Kim, J., & Iyer, V. R. (2004). Global role of TATA box-binding protein recruitment to promoters in mediating gene expression profiles. Molecular and cellular biology, 24(18), 8104–8112. doi:10.1128/MCB.24.18.8104-8112.2004
 

Revision as of 10:11, 14 September 2020

Your Heading Here (maybe something like 'Structure')

Caption for this structure

Drag the structure with the mouse to rotate

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
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