1cmb

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[[Image:1cmb.gif|left|200px]]
[[Image:1cmb.gif|left|200px]]
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{{Structure
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|PDB= 1cmb |SIZE=350|CAPTION= <scene name='initialview01'>1cmb</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1cmb", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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{{STRUCTURE_1cmb| PDB=1cmb | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cmb OCA], [http://www.ebi.ac.uk/pdbsum/1cmb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cmb RCSB]</span>
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'''THREE DIMENSIONAL CRYSTAL STRUCTURES OF ESCHERICHIA COLI MET REPRESSOR WITH AND WITHOUT COREPRESSOR'''
'''THREE DIMENSIONAL CRYSTAL STRUCTURES OF ESCHERICHIA COLI MET REPRESSOR WITH AND WITHOUT COREPRESSOR'''
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[[Category: Phillips, S E.V.]]
[[Category: Phillips, S E.V.]]
[[Category: Rafferty, J B.]]
[[Category: Rafferty, J B.]]
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[[Category: dna-binding regulatory protein]]
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[[Category: Dna-binding regulatory protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:53:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:24:27 2008''
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Revision as of 09:53, 2 May 2008

Image:1cmb.gif

Template:STRUCTURE 1cmb

THREE DIMENSIONAL CRYSTAL STRUCTURES OF ESCHERICHIA COLI MET REPRESSOR WITH AND WITHOUT COREPRESSOR


Overview

The three-dimensional crystal structure of met repressor, in the presence or absence of bound corepressor (S-adenosylmethionine), shows a dimer of intertwined monomers, which do not have the helix-turn-helix motif characteristic of other bacterial repressor and activator structures. We propose that the interaction of met repressor with DNA occurs through either a pair of symmetry-related alpha-helices or a pair of beta-strands, and suggest a model for binding of several dimers to met operator regions.

About this Structure

1CMB is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Three-dimensional crystal structures of Escherichia coli met repressor with and without corepressor., Rafferty JB, Somers WS, Saint-Girons I, Phillips SE, Nature. 1989 Oct 26;341(6244):705-10. PMID:2677753 Page seeded by OCA on Fri May 2 12:53:19 2008

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