3hyu

From Proteopedia

(Difference between revisions)

Revision as of 10:52, 16 September 2020

Crystal structure of the altitude adapted hemoglobin of guinea pig.

Structural highlights

3hyu is a 2 chain structure with sequence from Cavia porcellus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[HBA_CAVPO] Involved in oxygen transport from the lung to the various peripheral tissues. [HBB_CAVPO] Involved in oxygen transport from the lung to the various peripheral tissues.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

BACKGROUND: Guinea pigs are considered to be genetically adapted to a high altitude environment based on the consistent finding of a high oxygen affinity of their blood. METHODOLOGY/PRINCIPAL FINDINGS: The crystal structure of guinea pig hemoglobin at 1.8 A resolution suggests that the increased oxygen affinity of guinea pig hemoglobin can be explained by two factors, namely a decreased stability of the T-state and an increased stability of the R2-state. The destabilization of the T-state can be related to the substitution of a highly conserved proline (P44) to histidine (H44) in the alpha-subunit, which causes a steric hindrance with H97 of the beta-subunit in the switch region. The stabilization of the R2-state is caused by two additional salt bridges at the beta1/beta2 interface. CONCLUSIONS/SIGNIFICANCE: Both factors together are supposed to serve to shift the equilibrium between the conformational states towards the high affinity relaxed states resulting in an increased oxygen affinity.

Structure of the altitude adapted hemoglobin of guinea pig in the R2-state.,Pairet B, Jaenicke E PLoS One. 2010 Aug 24;5(8):e12389. PMID:20811494^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Pairet B, Jaenicke E. Structure of the altitude adapted hemoglobin of guinea pig in the R2-state. PLoS One. 2010 Aug 24;5(8):e12389. PMID:20811494 doi:10.1371/journal.pone.0012389

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3hyu"

@@ Line 1: / Line 1: @@
 ==Crystal structure of the altitude adapted hemoglobin of guinea pig.==
-<StructureSection load='3hyu' size='340' side='right' caption='[[3hyu]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
+<StructureSection load='3hyu' size='340' side='right'caption='[[3hyu]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3hyu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cavia_porcellus Cavia porcellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HYU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3hyu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cavia_porcellus Cavia porcellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HYU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3HYU FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hyu OCA], [http://pdbe.org/3hyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hyu RCSB], [http://www.ebi.ac.uk/pdbsum/3hyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hyu ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3hyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hyu OCA], [http://pdbe.org/3hyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hyu RCSB], [http://www.ebi.ac.uk/pdbsum/3hyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hyu ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 36: / Line 36: @@
 </StructureSection>
 [[Category: Cavia porcellus]]
+[[Category: Large Structures]]
 [[Category: Jaenicke, E]]
 [[Category: Pairet, B]]

3hyu

From Proteopedia

Revision as of 10:52, 16 September 2020

Crystal structure of the altitude adapted hemoglobin of guinea pig.

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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