P73

From Proteopedia

Revision as of 07:35, 17 September 2020

spinqualitylabelsall models Human p73 DNA-binding domain complex with Tris, glycerol and Zn+2 ion (grey), 2xwc Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image p73 is a protein related to p53 tumor suppressor. It is involved in cell cycle regulation and induction of apoptosis[1]. p73 has several variants differing in their C- or N-terminal. p73 contains DNA-binding domain (DBD residues 112-312); tetramerization domain (TD residues 351-398). Structural highlights . .

3D Structures of p73

Updated on 17-September-2020

Domains - DNA-binding (DBD) 112-311; Tetramerization (TD) 351-398; C-terminal 439-506.

1cok – hp73 C terminal – human – NMR

2kby – hp73 TD – NMR

2wqi, 2wqj, 2wtt - hp73 TD
5hob, 5hoc - hp73 TD (mutant)
2xwc – hp73 DBD (mutant)
2nb1 - hp73 TD (mutant) + hp63 TD (mutant)
3vd0, 3vd1, 3vd2, 4g82, 4g83, 4guo, 4guq, 5kbd – hp73 DBD + DNA
4a63 – hp73 DBD + apoptosis stimulating of p53 protein

References

1. ↑ Di Como CJ, Gaiddon C, Prives C. p73 function is inhibited by tumor-derived p53 mutants in mammalian cells. Mol Cell Biol. 1999 Feb;19(2):1438-49. PMID:9891077