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Phosphodiesterase 3D structures
From Proteopedia
(Difference between revisions)
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**[[1f0j]] – mPDE 2a regulatory domain (mutant) – mouse<BR /> | **[[1f0j]] – mPDE 2a regulatory domain (mutant) – mouse<BR /> | ||
**[[1z1l]], [[3ibj]], [[3itm]] - hPDE 2a catalytic domain<BR /> | **[[1z1l]], [[3ibj]], [[3itm]] - hPDE 2a catalytic domain<BR /> | ||
| - | **[[3itu]], [[4htx]], [[4htz]], [[4jib]], [[4d08]], [[4d09]], [[5xkm]], [[5vp0]], [[5vp1]], [[5u7l]], [[5u7k]], [[5u7j]], [[5u7i]], [[5u7d]], [[5u00]], [[5tzz]], [[5tzx]], [[5tzw]], [[5tzh]], [[5tzc]], [[5tza]], [[5tz3]], [[6ezf]], [[6c7j]], [[6c7i]], [[6c7g]], [[6c7f]], [[6c7e]], [[6c7d]], [[6b98]], [[6b97]], [[6b96]], [[4c1i]], [[6cyd]], [[6cyc]], [[6cyb]], [[6blf]] - hPDE 2a catalytic domain + inhibitor<br /> | + | **[[3itu]], [[4htx]], [[4htz]], [[4jib]], [[4d08]], [[4d09]], [[5xkm]], [[5vp0]], [[5vp1]], [[5u7l]], [[5u7k]], [[5u7j]], [[5u7i]], [[5u7d]], [[5u00]], [[5tzz]], [[5tzx]], [[5tzw]], [[5tzh]], [[5tzc]], [[5tza]], [[5tz3]], [[6ezf]], [[6c7j]], [[6c7i]], [[6c7g]], [[6c7f]], [[6c7e]], [[6c7d]], [[6b98]], [[6b97]], [[6b96]], [[4c1i]], [[6cyd]], [[6cyc]], [[6cyb]], [[6blf]], [[6znd]] - hPDE 2a catalytic domain + inhibitor<br /> |
**[[1f0j]] – mPDE 2a regulatory domain (mutant) – mouse<BR /> | **[[1f0j]] – mPDE 2a regulatory domain (mutant) – mouse<BR /> | ||
**[[6cpu]] - CaPDE 2 – ''Candida albicans''<br /> | **[[6cpu]] - CaPDE 2 – ''Candida albicans''<br /> | ||
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**[[2qym]] – hPDE 4c catalytic domain | **[[2qym]] – hPDE 4c catalytic domain | ||
| - | *PDE 4d or cAMP-specific 3’5’-cyclic PDE 4d | + | *PDE 4d or cAMP-specific 3’5’-cyclic PDE 4d |
**[[1e9k]] - hPDE 4d5 N terminal – NMR<BR /> | **[[1e9k]] - hPDE 4d5 N terminal – NMR<BR /> | ||
**[[1mkd]], [[1oyn]], [[1q9m]], [[1tbb]], [[1xoq]], [[3g4k]], [[3g4l]] - hPDE 4d catalytic domain + anti-inflammatory drug<br /> | **[[1mkd]], [[1oyn]], [[1q9m]], [[1tbb]], [[1xoq]], [[3g4k]], [[3g4l]] - hPDE 4d catalytic domain + anti-inflammatory drug<br /> | ||
| - | **[[1xlx]], [[1xlz]], [[1xm4]], [[1xm6]], [[1xmu]], [[1xom]], [[1xon]], [[1xor]], [[1xos]], [[3iak]] - hPDE 4d catalytic domain + drug<br /> | + | **[[1xlx]], [[1xlz]], [[1xm4]], [[1xm6]], [[1xmu]], [[1xom]], [[1xon]], [[1xor]], [[1xos]], [[3iak]], [[6kjz]], [[6kk0]] - hPDE 4d catalytic domain + drug<br /> |
**[[1ptw]], [[1tb7]] - hPDE 4d catalytic domain + AMP<BR /> | **[[1ptw]], [[1tb7]] - hPDE 4d catalytic domain + AMP<BR /> | ||
**[[2pw3]] - hPDE 4d catalytic domain (mutant) + AMP<BR /> | **[[2pw3]] - hPDE 4d catalytic domain (mutant) + AMP<BR /> | ||
| - | **[[1y2b]], [[1y2c]], [[1y2d]], [[1y2e]], [[1y2k]], [[1zkn]], [[2fm0]], [[2fm5]], [[2qyn]], [[3k4s]], [[3sl3]], [[3sl4]], [[3sl5]], [[3sl6]], [[3sl8]], [[3v9b]], [[5wqa]], [[5tkb]], [[5k32]], [[5k1i]], [[4wcu]], [[4w1o]], [[4ogb]], [[6fdc]], [[6f8x]], [[6f8w]], [[6f8v]], [[6f8u]], [[6f8t]], [[6f8r]], [[6f6u]], [[5wh6]], [[5wh5]], [[5lbo]], [[6rcw]], [[6inm]], [[6ink]], [[6ind]], [[6imt]], [[6imr]], [[6imo]], [[6imd]], [[6imi]], [[6imb]], [[6im6]], [[6hwo]], [[6fw3]], [[6ftw]], [[6fta]], [[6ft0]], [[6fet]], [[6feb]], [[6fe7]], [[6fdi]], [[6boj]] - hPDE 4d catalytic domain + inhibitor<br /> | + | **[[1y2b]], [[1y2c]], [[1y2d]], [[1y2e]], [[1y2k]], [[1zkn]], [[2fm0]], [[2fm5]], [[2qyn]], [[3k4s]], [[3sl3]], [[3sl4]], [[3sl5]], [[3sl6]], [[3sl8]], [[3v9b]], [[5wqa]], [[5tkb]], [[5k32]], [[5k1i]], [[4wcu]], [[4w1o]], [[4ogb]], [[6fdc]], [[6f8x]], [[6f8w]], [[6f8v]], [[6f8u]], [[6f8t]], [[6f8r]], [[6f6u]], [[5wh6]], [[5wh5]], [[5lbo]], [[6rcw]], [[6inm]], [[6ink]], [[6ind]], [[6imt]], [[6imr]], [[6imo]], [[6imd]], [[6imi]], [[6imb]], [[6im6]], [[6hwo]], [[6fw3]], [[6ftw]], [[6fta]], [[6ft0]], [[6fet]], [[6feb]], [[6fe7]], [[6fdi]], [[6boj]], [[6iag]], [[6ibf]] - hPDE 4d catalytic domain + inhibitor<br /> |
**[[6njj]], [[6nji]], [[6njh]] - hPDE 4d catalytic domain (mutant) + inhibitor<br /> | **[[6njj]], [[6nji]], [[6njh]] - hPDE 4d catalytic domain (mutant) + inhibitor<br /> | ||
**[[3iad]], [[3g4g]], [[3g4i]], [[3g58]] - hPDE 4d catalytic domain + modulator | **[[3iad]], [[3g4g]], [[3g4i]], [[3g58]] - hPDE 4d catalytic domain + modulator | ||
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**[[3lfv]], [[3mf0]], [[2xss]] - hPDE 5a GAF domain<BR /> | **[[3lfv]], [[3mf0]], [[2xss]] - hPDE 5a GAF domain<BR /> | ||
**[[1rkp]], [[3tgg]] – hPDE 5a1 catalytic domain (mutant) + inhibitor<br /> | **[[1rkp]], [[3tgg]] – hPDE 5a1 catalytic domain (mutant) + inhibitor<br /> | ||
| - | **[[2chm]], [[4oex]], [[4oew]], [[4g2w]], [[4g2y]], [[4i9z]], [[4ia0]], [[4md6]], [[5jo3]], [[6acb]], [[5zz2]] - hPDE 5a catalytic domain + inhibitor<br /> | + | **[[2chm]], [[4oex]], [[4oew]], [[4g2w]], [[4g2y]], [[4i9z]], [[4ia0]], [[4md6]], [[5jo3]], [[6acb]], [[5zz2]], [[6iwi]] - hPDE 5a catalytic domain + inhibitor<br /> |
**[[2h44]], [[3bjc]], [[3hc8]], [[3hdz]], [[3shy]], [[3shz]], [[3sie]], [[3tge]] - hPDE 5a1 catalytic domain + inhibitor<br /> | **[[2h44]], [[3bjc]], [[3hc8]], [[3hdz]], [[3shy]], [[3shz]], [[3sie]], [[3tge]] - hPDE 5a1 catalytic domain + inhibitor<br /> | ||
| - | **[[1udt]], [[1udu]], [[1uho]], [[1tbf]], [[1xoz]], [[1xp0]], [[2h42]], [[3b2r]] - hPDE 5 catalytic domain + drug<br /> | + | **[[1udt]], [[1udu]], [[1uho]], [[1tbf]], [[1xoz]], [[1xp0]], [[2h42]], [[3b2r]], [[6l6e]] - hPDE 5 catalytic domain + drug<br /> |
**[[3jwq]] - hPDE 5/hPDE 6 catalytic domain + drug<br /> | **[[3jwq]] - hPDE 5/hPDE 6 catalytic domain + drug<br /> | ||
**[[3jwr]] - hPDE 5/hPDE 6 catalytic domain + hPDE γ subunit peptide + inhibitor<br /> | **[[3jwr]] - hPDE 5/hPDE 6 catalytic domain + hPDE γ subunit peptide + inhibitor<br /> | ||
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**[[2zmf]] – hPDE 10a C terminal<BR /> | **[[2zmf]] – hPDE 10a C terminal<BR /> | ||
**[[2ous]], [[2ouv]] - hPDE 10a2 catalytic domain (mutant) <BR /> | **[[2ous]], [[2ouv]] - hPDE 10a2 catalytic domain (mutant) <BR /> | ||
| - | **[[2qyk]], [[3lxg]], [[2y0j]], [[3qpn]], [[3qpo]], [[3qpp]], [[3sn7]], [[3sni]], [[3snl]], [[3wi2]], [[4ael]], [[4ajd]], [[4ajf]], [[4ajg]], [[4ajm]], [[4ddl]], [[4fcb]], [[4fcd]], [[4heu]], [[4hf4]], [[4lkq]], [[4llj]], [[4llk]], [[4llp]], [[4llx]], [[4lm0]], [[4lm1]], [[4lm2]], [[4lm3]], [[4lm4]], [[4muw]], [[4mvh]], [[4yqh]], [[4ys7]], [[3ws8]], [[3ws9]], [[3wyk]], [[3wyl]], [[3wym]], [[4mrw]], [[4mrz]], [[4ms0]], [[4msa]], [[4msc]], [[4mse]], [[4msh]], [[4msn]], [[5uwf]], [[5k9r]], [[5i2r]], [[5edi]], [[5edh]], [[5edg]], [[5ede]], [[5dh5]], [[5dh4]], [[5c2h]], [[5c2e]], [[5c2a]], [[5c29]], [[5c28]], [[5c1w]], [[5b4k]], [[5b4l]], [[5axq]], [[5axp]], [[4zo5]], [[4xy2]], [[4wn1]], [[4tpp]], [[4tpm]], [[4phw]], [[4p1r]], [[4p0n]], [[5xuj]], [[5xui]], | + | **[[2qyk]], [[3lxg]], [[2y0j]], [[3qpn]], [[3qpo]], [[3qpp]], [[3sn7]], [[3sni]], [[3snl]], [[3wi2]], [[4ael]], [[4ajd]], [[4ajf]], [[4ajg]], [[4ajm]], [[4ddl]], [[4fcb]], [[4fcd]], [[4heu]], [[4hf4]], [[4lkq]], [[4llj]], [[4llk]], [[4llp]], [[4llx]], [[4lm0]], [[4lm1]], [[4lm2]], [[4lm3]], [[4lm4]], [[4muw]], [[4mvh]], [[4yqh]], [[4ys7]], [[3ws8]], [[3ws9]], [[3wyk]], [[3wyl]], [[3wym]], [[4mrw]], [[4mrz]], [[4ms0]], [[4msa]], [[4msc]], [[4mse]], [[4msh]], [[4msn]], [[5uwf]], [[5k9r]], [[5i2r]], [[5edi]], [[5edh]], [[5edg]], [[5ede]], [[5dh5]], [[5dh4]], [[5c2h]], [[5c2e]], [[5c2a]], [[5c29]], [[5c28]], [[5c1w]], [[5b4k]], [[5b4l]], [[5axq]], [[5axp]], [[4zo5]], [[4xy2]], [[4wn1]], [[4tpp]], [[4tpm]], [[4phw]], [[4p1r]], [[4p0n]], [[5xuj]], [[5xui]], [[6msc]], [[6msa]], [[6ke0]], [[6kdz]], [[6kdx]], [[6iji]], [[6ijh]], [[5znl]], [[6ko0]], [[6ko1]] - hPDE 10a catalytic domain + inhibitor<br /> |
**[[2wey]], [[3hqw]], [[3hqy]], [[3hqz]], [[3hr1]], [[3ui7]], [[3uuo]], [[4bbx]], [[4dff]] - hPDE 10a catalytic domain + schizophrenia drug<br /> | **[[2wey]], [[3hqw]], [[3hqy]], [[3hqz]], [[3hr1]], [[3ui7]], [[3uuo]], [[4bbx]], [[4dff]] - hPDE 10a catalytic domain + schizophrenia drug<br /> | ||
**[[2oun]] - hPDE 10a2 catalytic domain + AMP<BR /> | **[[2oun]] - hPDE 10a2 catalytic domain + AMP<BR /> | ||
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**[[4i15]] – TbPDEb1 catalytic domain – ''Trypanosoma brucei''<br /> | **[[4i15]] – TbPDEb1 catalytic domain – ''Trypanosoma brucei''<br /> | ||
| - | **[[5l9h]], [[5l8y]], [[5l8c]], [[5g5v]], [[5g57]], [[5g2b]], [[4phl]], [[6rgk]], [[6rfw]], [[6rfn]], [[6rb6]], [[6gxq]], [[6fv9]], [[6ftm]], [[6frd]], [[6fe3]], [[6fdx]], [[6fdw]], [[6fds]] – TbPDEb1 catalytic domain + inhibitor<br /> | + | **[[5l9h]], [[5l8y]], [[5l8c]], [[5g5v]], [[5g57]], [[5g2b]], [[4phl]], [[6rgk]], [[6rfw]], [[6rfn]], [[6rb6]], [[6gxq]], [[6fv9]], [[6ftm]], [[6frd]], [[6fe3]], [[6fdx]], [[6fdw]], [[6fds]], [[6qgp]], [[6qgu]] – TbPDEb1 catalytic domain + inhibitor<br /> |
*PDE b2 | *PDE b2 | ||
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**[[5j3s]], [[5j3p]] - hPDE catalytic domain (mutant) + inhibitor<br /> | **[[5j3s]], [[5j3p]] - hPDE catalytic domain (mutant) + inhibitor<br /> | ||
**[[5nwa]], [[5nw9]] – hPDE1 residues 1-148 + DNA <br /> | **[[5nwa]], [[5nw9]] – hPDE1 residues 1-148 + DNA <br /> | ||
| + | **[[6q00]], [[6q01]] - hPDE UBA domain 25-66 + ubiquitin<br /> | ||
**[[5j3s]], [[5j3p]] - hPDE1 catalytic domain (mutant) + inhibitor<br /> | **[[5j3s]], [[5j3p]] - hPDE1 catalytic domain (mutant) + inhibitor<br /> | ||
**[[5inm]] - mPDE catalytic domain <br /> | **[[5inm]] - mPDE catalytic domain <br /> | ||
Revision as of 08:58, 22 September 2020
3D Structures of phosphodiesterase
Updated on 22-September-2020
