1cnt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1cnt.gif|left|200px]]
[[Image:1cnt.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1cnt |SIZE=350|CAPTION= <scene name='initialview01'>1cnt</scene>, resolution 2.4&Aring;
+
The line below this paragraph, containing "STRUCTURE_1cnt", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= HUMAN CNTF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1cnt| PDB=1cnt | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cnt OCA], [http://www.ebi.ac.uk/pdbsum/1cnt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cnt RCSB]</span>
+
-
}}
+
'''CILIARY NEUROTROPHIC FACTOR'''
'''CILIARY NEUROTROPHIC FACTOR'''
Line 28: Line 25:
[[Category: Mcdonald, N Q.]]
[[Category: Mcdonald, N Q.]]
[[Category: Panayotatos, N.]]
[[Category: Panayotatos, N.]]
-
[[Category: cytokine]]
+
[[Category: Cytokine]]
-
[[Category: growth factor]]
+
[[Category: Growth factor]]
-
[[Category: neurotrophic factor]]
+
[[Category: Neurotrophic factor]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:55:50 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:25:09 2008''
+

Revision as of 09:55, 2 May 2008

Image:1cnt.gif

Template:STRUCTURE 1cnt

CILIARY NEUROTROPHIC FACTOR


Overview

Ciliary neurotrophic factor (CNTF) promotes the survival and differentiation of developing motor neurons and is a potential therapeutic for treating neurodegeneration and nerve injury. The crystal structure of human CNTF has been determined at 2.4 A resolution using multi-wavelength anomalous diffraction (MAD) phasing from a single Yb3+ ions. The structure reveals that CNTF is dimeric, with a novel anti-parallel arrangement of the subunits, not previously observed for other cytokines. Each subunit adopts a double crossover four-helix bundle fold, in which two helices contribute to the dimer interface, whilst two different helices show pronounced kinks. Analysis of the electrostatic surface of CNTF identified residues within these kinked helices that may contact the CNTF receptor-alpha. Solution experiments show that CNTF dimerizes at concentrations > 40 microM. Such dimers are likely to be relevant to the storage of CNTF in the peripheral nerve given the high concentrations present in this tissue. However, it is unlikely that they play a role in engaging the three distinct receptor subunits that comprise the CNTF receptor, given the low concentration of extracellular CNTF and its high potency.

About this Structure

1CNT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing., McDonald NQ, Panayotatos N, Hendrickson WA, EMBO J. 1995 Jun 15;14(12):2689-99. PMID:7796798 Page seeded by OCA on Fri May 2 12:55:50 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1cnt"
Personal tools