1cov
From Proteopedia
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'''COXSACKIEVIRUS B3 COAT PROTEIN''' | '''COXSACKIEVIRUS B3 COAT PROTEIN''' | ||
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[[Category: Muckelbauer, J K.]] | [[Category: Muckelbauer, J K.]] | ||
[[Category: Rossmann, M G.]] | [[Category: Rossmann, M G.]] | ||
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| - | [[Category: | + | [[Category: Icosahedral virus]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:57:36 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 09:57, 2 May 2008
COXSACKIEVIRUS B3 COAT PROTEIN
Overview
The crystal structure of coxsackievirus B3 (CVB3) has been determined to 3.5 A resolution. The icosahedral CVB3 particles crystallize in the monoclinic space group, P2(1), (a = 574.6, b = 302.1, c = 521.6 A, beta = 107.7 degrees ) with two virions in the asymmetric unit giving 120-fold non-crystallographic redundancy. The crystals diffracted to 2.7 A resolution and the X-ray data set was 55% complete to 3.0,4, resolution. Systematically weak reflections and the self-rotation function established pseudo R32 symmetry with each particle sitting on a 32 special position. This constrained the orientation and position of each particle in the monoclinic cell to near face-centered positions and allowed for a total of six possible monoclinic space-group settings. Correct interpretation of the high-resolution (3.0-3.2 A) self-rotation function was instrumental in determining the deviations from R32 orientations of the virus particles in the unit cell. Accurate particle orientations permitted the correct assignment of the crystal space-group setting amongst the six ambiguous possibilities and for the correct determination of particle positions. Real-space electron-density averaging and phase refinement, using human rhinovius 14 (HRV14) as an initial phasing model, have been carried out to 3.5 A resolution. The initial structural model has been built and refined to 3.5 A resolution using X-PLOR.
About this Structure
1COV is a Single protein structure of sequence from Human coxsackievirus b3. Full crystallographic information is available from OCA.
Reference
Structure determination of coxsackievirus B3 to 3.5 A resolution., Muckelbauer JK, Kremer M, Minor I, Tong L, Zlotnick A, Johnson JE, Rossmann MG, Acta Crystallogr D Biol Crystallogr. 1995 Nov 1;51(Pt 6):871-87. PMID:15299757 Page seeded by OCA on Fri May 2 12:57:36 2008
