5vxk
From Proteopedia
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==2.55 A resolution structure of IpaD from Shigella flexneri in complex with single-domain antibody JMK-H2== | ==2.55 A resolution structure of IpaD from Shigella flexneri in complex with single-domain antibody JMK-H2== | ||
| - | <StructureSection load='5vxk' size='340' side='right' caption='[[5vxk]], [[Resolution|resolution]] 2.55Å' scene=''> | + | <StructureSection load='5vxk' size='340' side='right'caption='[[5vxk]], [[Resolution|resolution]] 2.55Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5vxk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VXK OCA]. For a <b>guided tour on the structure components</b> use [http:// | + | <table><tr><td colspan='2'>[[5vxk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VXK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5VXK FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http:// | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5vxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vxk OCA], [http://pdbe.org/5vxk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vxk RCSB], [http://www.ebi.ac.uk/pdbsum/5vxk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vxk ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/IPAD_SHIFL IPAD_SHIFL]] Required for bacterial invasion of host cells. Controls IpaB and IpaC secretion, and the efficiency with which they are physically inserted into target cell membranes. These proteins are exported via TTSS to form a pore in the host membrane that allows the translocation of the other effectors into the host cytoplasm. Along with IpaB, is essential for both blocking secretion through the Mxi/Spa translocon in the absence of a secretion-inducing signal, and for controlling the level of secretion in the presence of this signal.<ref>PMID:7957095</ref> <ref>PMID:15731041</ref> | [[http://www.uniprot.org/uniprot/IPAD_SHIFL IPAD_SHIFL]] Required for bacterial invasion of host cells. Controls IpaB and IpaC secretion, and the efficiency with which they are physically inserted into target cell membranes. These proteins are exported via TTSS to form a pore in the host membrane that allows the translocation of the other effectors into the host cytoplasm. Along with IpaB, is essential for both blocking secretion through the Mxi/Spa translocon in the absence of a secretion-inducing signal, and for controlling the level of secretion in the presence of this signal.<ref>PMID:7957095</ref> <ref>PMID:15731041</ref> | ||
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| + | ==See Also== | ||
| + | *[[Antibody 3D structures|Antibody 3D structures]] | ||
| + | *[[3D structures of non-human antibody|3D structures of non-human antibody]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Barta, M L]] | [[Category: Barta, M L]] | ||
[[Category: Battaile, K P]] | [[Category: Battaile, K P]] | ||
Revision as of 08:45, 30 September 2020
2.55 A resolution structure of IpaD from Shigella flexneri in complex with single-domain antibody JMK-H2
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Categories: Large Structures | Barta, M L | Battaile, K P | Lovell, S | Picking, W D | Picking, W L | Immune system | T3ss | Tip protein | Vhh
