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1cq3

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[[Image:1cq3.jpg|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cq3 OCA], [http://www.ebi.ac.uk/pdbsum/1cq3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cq3 RCSB]</span>
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'''STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS'''
'''STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS'''
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[[Category: Smolak, P J.]]
[[Category: Smolak, P J.]]
[[Category: Wiley, D C.]]
[[Category: Wiley, D C.]]
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[[Category: beta sandwich]]
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[[Category: Beta sandwich]]
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[[Category: chemokine]]
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[[Category: Chemokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:59:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:26:20 2008''
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Revision as of 09:59, 2 May 2008

Image:1cq3.jpg

Template:STRUCTURE 1cq3

STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS


Overview

Most poxviruses, including variola, the causative agent of smallpox, express a secreted protein of 35 kDa, vCCI, which binds CC-chemokines with high affinity. This viral protein competes with the host cellular CC-chemokine receptors (CCRs), reducing inflammation and interfering with the host immune response. Such proteins or derivatives may have therapeutic uses as anti-inflammatory agents. We have determined the crystal structure to 1.85-A resolution of vCCI from cowpox virus, the prototype of this poxvirus virulence factor. The molecule is a beta-sandwich of topology not previously described. A patch of conserved residues on the exposed face of a beta-sheet that is strongly negatively charged might have a role in binding of CC-chemokines, which are positively charged.

About this Structure

1CQ3 is a Single protein structure of sequence from Cowpox virus. Full crystallographic information is available from OCA.

Reference

Structure of a soluble secreted chemokine inhibitor vCCI (p35) from cowpox virus., Carfi A, Smith CA, Smolak PJ, McGrew J, Wiley DC, Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12379-83. PMID:10535930 Page seeded by OCA on Fri May 2 12:59:37 2008

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