1cq3
From Proteopedia
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'''STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS''' | '''STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS''' | ||
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[[Category: Smolak, P J.]] | [[Category: Smolak, P J.]] | ||
[[Category: Wiley, D C.]] | [[Category: Wiley, D C.]] | ||
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| - | [[Category: | + | [[Category: Chemokine]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:59:37 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 09:59, 2 May 2008
STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS
Overview
Most poxviruses, including variola, the causative agent of smallpox, express a secreted protein of 35 kDa, vCCI, which binds CC-chemokines with high affinity. This viral protein competes with the host cellular CC-chemokine receptors (CCRs), reducing inflammation and interfering with the host immune response. Such proteins or derivatives may have therapeutic uses as anti-inflammatory agents. We have determined the crystal structure to 1.85-A resolution of vCCI from cowpox virus, the prototype of this poxvirus virulence factor. The molecule is a beta-sandwich of topology not previously described. A patch of conserved residues on the exposed face of a beta-sheet that is strongly negatively charged might have a role in binding of CC-chemokines, which are positively charged.
About this Structure
1CQ3 is a Single protein structure of sequence from Cowpox virus. Full crystallographic information is available from OCA.
Reference
Structure of a soluble secreted chemokine inhibitor vCCI (p35) from cowpox virus., Carfi A, Smith CA, Smolak PJ, McGrew J, Wiley DC, Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12379-83. PMID:10535930 Page seeded by OCA on Fri May 2 12:59:37 2008
