Cystathionine gamma synthase

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(New page: <StructureSection load='1i41' size='340' side='right' caption='Tobacco cystathionine gamma synthatase complex with inhibitor (PDB code 1i41)' scene=''> == Function == '''Cystathioni...)
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<StructureSection load='1i41' size='340' side='right' caption='Tobacco cystathionine gamma synthatase complex with inhibitor (PDB code [[1i41]])' scene=''>
<StructureSection load='1i41' size='340' side='right' caption='Tobacco cystathionine gamma synthatase complex with inhibitor (PDB code [[1i41]])' scene=''>
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== Structural highlights ==
== Structural highlights ==
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The 3D structure of tobacco CGS complex with an inhibitor shows the interaction of the inhibitor in the substrate binding pocket of CGS dimer. The carboxylate moiety of the inhibitor makes hydrogen bond to Arg and its phosphonate group binds to phosphate recognition group formed by residues from both monomers<ref>PMID:11518531</ref>.
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Revision as of 06:30, 4 October 2020

Tobacco cystathionine gamma synthatase complex with inhibitor (PDB code 1i41)

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3D structures of cystathionine gamma synthase

1i41 - tCGS + inhibitor - tobacco
1qgn - tCGS + PLP
1i43, 1i48 - tCGS + PLP + inhibitor
1cs1 - CGS + PLP derivative - Eschericia coli
4l0o - CGS + PLP - Helicobacter pylori
6s0c - CGS + PLP - Citrobacter freundii
3qi6, 3qhx - CGS MetB - Mycobacterium ulcerans
5x5h - CGS MetB - Corynebacterium glutamicum

References

  1. ↑ Flavin M, Slaughter C. Enzymatic synthesis of homocysteine or methionine directly from O-succinyl-homoserine. Biochim Biophys Acta. 1967 Mar 15;132(2):400-5. doi:, 10.1016/0005-2744(67)90158-1. PMID:5340123 doi:http://dx.doi.org/10.1016/0005-2744(67)90158-1
  2. ↑ Fu J, Wu J, Jiang J, Wang Z, Ma Z. Cystathionine gamma-synthase is essential for methionine biosynthesis in Fusarium graminearum. Fungal Biol. 2013 Jan;117(1):13-21. doi: 10.1016/j.funbio.2012.11.001. Epub 2012 , Dec 1. PMID:23332829 doi:http://dx.doi.org/10.1016/j.funbio.2012.11.001
  3. ↑ Steegborn C, Laber B, Messerschmidt A, Huber R, Clausen T. Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor. J Mol Biol. 2001 Aug 24;311(4):789-801. PMID:11518531 doi:10.1006/jmbi.2001.4880

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Alexander Berchansky, Michal Harel

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