1cqt

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[[Image:1cqt.gif|left|200px]]
[[Image:1cqt.gif|left|200px]]
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{{Structure
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|PDB= 1cqt |SIZE=350|CAPTION= <scene name='initialview01'>1cqt</scene>, resolution 3.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1cqt", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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|GENE=
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{{STRUCTURE_1cqt| PDB=1cqt | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cqt OCA], [http://www.ebi.ac.uk/pdbsum/1cqt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cqt RCSB]</span>
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'''CRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT'''
'''CRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT'''
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[[Category: Pabo, C O.]]
[[Category: Pabo, C O.]]
[[Category: Sharp, P A.]]
[[Category: Sharp, P A.]]
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[[Category: gene regulation/dna]]
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[[Category: Gene regulation/dna]]
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[[Category: oca-b]]
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[[Category: Oca-b]]
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[[Category: oct1]]
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[[Category: Oct1]]
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[[Category: pou domain]]
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[[Category: Pou domain]]
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[[Category: protein-dna complex]]
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[[Category: Protein-dna complex]]
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[[Category: protein-dna interface]]
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[[Category: Protein-dna interface]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:01:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:26:52 2008''
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Revision as of 10:01, 2 May 2008

Image:1cqt.gif

Template:STRUCTURE 1cqt

CRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT


Overview

We have determined the crystal structure, at 3.2 A, of a ternary complex containing an OCA-B peptide, the Oct-1 POU domain, and an octamer DNA site. The OCA-B peptide binds in the major groove near the center of the octamer site, and its polypeptide backbone forms a pair of hydrogen bonds with the adenine base at position 5 of the octamer DNA. Numerous protein-protein contacts between the OCA-B peptide and the POU domain are also involved in the ternary complex. In particular, the hydrophobic surface from a short alpha-helix of OCA-B helps to stabilize the complex by binding to a hydrophobic pocket on the POU-specific domain. The structure of this ternary complex is consistent with previous biochemical studies and shows how peptide-DNA and peptide-protein contacts from OCA-B provide structural and functional specificity in the regulation of immunoglobulin transcription.

About this Structure

1CQT is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface., Chasman D, Cepek K, Sharp PA, Pabo CO, Genes Dev. 1999 Oct 15;13(20):2650-7. PMID:10541551 Page seeded by OCA on Fri May 2 13:01:03 2008

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